EVIDENCE FOR L-DOPA SYSTEMS RESPONSIBLE FOR CARDIOVASCULAR CONTROL IN THE NUCLEUS-TRACTUS-SOLITARII OF THE RAT

被引：62

作者：

KUBO, T ^{[1
]}

YUE, JL ^{[1
]}

GOSHIMA, Y ^{[1
]}

NAKAMURA, S ^{[1
]}

MISU, Y ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV, SCH MED, DEPT PHARMACOL, YOKOHAMA 236, JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 02期

关键词：

L-DOPA; D-DOPA; L-DOPA METHYL ESTER; COMPETITIVE L-DOPA ANTAGONIST; DOPAMINE; NORADRENALINE; NUCLEUS-TRACTUS-SOLITARII; BLOOD PRESSURE; RELEASE OF ENDOGENOUS DOPA; RAT;

D O I：

10.1016/0304-3940(92)90090-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjections of L-DOPA (10-100 ng) into the medial area of the nucleus tractus solitarii (NTS) led to dose-dependent decreases in arterial blood pressure and heart rate in rats treated with i.p. 3-hydroxybenzylhydrazine, a central inhibitor of DOPA decarboxylase, or similarly with intraventricular 6-hydroxydopamine. D-DOPA, dopamine or noradrenaline (100 ng) produced no effect. L-DOPA methyl ester (1-mu-g), a competitive antagonist for L-DOPA, microinjected into NTS. blocked the depressor and bradycardic responses to L-DOPA. High K+ (40 mM) released endogenous DOPA in a Ca2+-dependent manner from slices of the rat dorsomedial medulla including NTS. These results support the hypothesis that there exist systems Of L-DOPA itself responsible for cardiovascular regulation in NTS of rats. This regulatory action Of L-DOPA seems to be postsynaptic in nature.

引用

页码：153 / 156

页数：4

共 48 条

[1] SPERMIDINE AND CARDIOVASCULAR CONTROL IN NUCLEUS-TRACTUS-SOLITARII IN RAT
OHTA, H
LEWIS, SJ
TALMAN, WT
BRAIN RESEARCH, 1993, 620 (01) : 72 - 77
[2] GLYCINE ELICITS RELEASE OF ACETYLCHOLINE FROM THE NUCLEUS-TRACTUS-SOLITARII IN RAT
TALMAN, WT
WELLENDORF, L
MARTINEZ, D
ELLISON, S
LI, XF
CASSELL, M
OHTA, H
BRAIN RESEARCH, 1994, 650 (02) : 253 - 259
[3] EVIDENCE FOR A KYNURENATE-INSENSITIVE GLUTAMATE RECEPTOR IN NUCLEUS-TRACTUS-SOLITARII
PAWLOSKIDAHM, C
GORDON, FJ
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (05): : H1611 - H1615
[4] L-DOPA INHIBITS EXCITATORY SYNAPTIC TRANSMISSION IN THE RAT NUCLEUS TRACTUS SOLITARIUS THROUGH RELEASE OF DOPAMINE
Ohi, Y.
Kodama, D.
Haji, A.
NEUROSCIENCE, 2017, 360 : 18 - 27
[5] CHARACTERISTIC FIRING BEHAVIOR OF CELL-TYPES IN THE CARDIORESPIRATORY REGION OF THE NUCLEUS-TRACTUS-SOLITARII OF THE RAT
PATON, JFR
FOSTER, WR
SCHWABER, JS
BRAIN RESEARCH, 1993, 604 (1-2) : 112 - 125
[6] EVIDENCE THAT ENDOGENOUS CATECHOLAMINES ARE INVOLVED IN ALPHA-2-ADRENOCEPTOR-MEDIATED MODULATION OF THE AORTIC BARORECEPTOR REFLEX IN THE NUCLEUS-TRACTUS-SOLITARII OF THE RAT
KUBO, T
GOSHIMA, Y
HATA, H
MISU, Y
BRAIN RESEARCH, 1990, 526 (02) : 313 - 317
[7] Depressor action of L-threo-dihydroxyphenylserine in the rat nucleus tractus solitarii
Miyamae, T
Yue, JL
Goshima, Y
Misu, Y
EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 300 (1-2) : 105 - 108
[8] ALTERED CARDIOVASCULAR-RESPONSES TO GLUTAMATE AND ACETYLCHOLINE MICROINJECTED INTO THE NUCLEUS-TRACTUS-SOLITARII OF THE SHR
TALMAN, WT
LEWIS, SJ
CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1991, 13 (05) : 661 - 668
[9] EVIDENCE FOR AN ANTAGONISTIC ANGIOTENSIN-II ALPHA(2)-ADRENOCEPTOR INTERACTION IN THE NUCLEUS-TRACTUS-SOLITARII
FIOR, DR
YANG, SN
HEDLUND, PB
NARVAEZ, JA
AGNATI, LF
FUXE, K
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 262 (03) : 271 - 282
[10] The evidence for tonic GABAergic regulation of basal L-DOPA release via activation of inhibitory GABAA receptors in the nucleus tractus solitarii of anesthetized rats
Goshima, Y
Honjo, K
Miyamae, T
Misu, Y
NEUROSCIENCE LETTERS, 1999, 261 (03) : 155 - 158

← 1 2 3 4 5 →