FETAL ALCOHOL DELAYS THE DEVELOPMENTAL EXPRESSION OF MYELIN BASIC-PROTEIN AND TRANSFERRIN IN RAT PRIMARY OLIGODENDROCYTE CULTURES

被引：38

作者：

CHIAPPELLI, F

TAYLOR, AN

DELOSMONTEROS, AE

DEVELLIS, J

机构：

[1] UNIV CALIF LOS ANGELES,BRAIN RES INST,PSYCHONEUROIMMUNOL RES PROGRAM,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,DEPT PSYCHIAT & BEHAV SCI,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024

[5] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

[6] VET ADM MED CTR,BRENTWOOD DIV,LOS ANGELES,CA 90073

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1991年 / 9卷 / 01期

关键词：

FETAL ALCOHOL; MYELIN BASIC PROTEIN; TRANSFERRIN; GLIAL CELL CULTURE; OLIGODENDROCYTE; IMMUNOCYTOCHEMISTRY;

D O I：

10.1016/0736-5748(91)90074-V

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study has examined the development of immunoreactive myelin basic protein and transferrin in primary glial cell cultures. Cultures were initiated from control and experimental Sprague-Dawley rats 1-2 days postnatally. Experimental treatment involved exposure to 5% (w/v) ethanol in a liquid diet during the last two weeks of gestation. Prenatal alcohol administration delayed the expression of myelin basic protein and transferrin during the first three weeks postnatally. Other oligodendroglial and astroglial markers were little affected, if at all, by fetal alcohol exposure.

引用

页码：67 / 75

页数：9

共 14 条

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