MOLECULAR TARGETS IN PERNICIOUS-ANEMIA

被引：73

作者：

GLEESON, PA

TOH, BH

机构：

[1] Dept of Pathology and Immunology, Monash University Medical School, Prahran

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0167-5699(91)90036-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune gastritis, leading to pernicious anaemia, is an organ-specific autoimmune disease characterized by chronic atrophic gastritis and circulating gastric parietal cell autoantibodies. The parietal cell autoantigens have recently been identified as the alpha and beta-subunit of the gastric proton pump (H+,K+ ATPase). Here Paul Gleeson and Ban-Hock Toh discuss how the identification of these gastric parietal cell autoantigens and the development of a mouse model of autoimmune gastritis have paved the way for an understanding of the pathogenesis of the gastric lesion.

引用

页码：233 / 238

页数：6

共 55 条

[1]

ABE R, 1989, ANNU REV IMMUNOL, V7, P683, DOI 10.1146/annurev.iy.07.040189.003343

[2]

BERGLINDH T, 1980, AM J PHYSIOL, V238, pG165, DOI 10.1152/ajpgi.1980.238.3.G165

[3]

BLACK JA, 1980, AM J PHYSIOL, V256, pG1070

[4] A ROLE FOR CLONAL INACTIVATION IN T-CELL TOLERANCE TO MLS-1A [J].