TRIAZOLAM AND PHASE-SHIFTING ACCELERATION REEVALUATED

被引：78
作者：
MROSOVSKY, N
SALMON, PA
机构：
[1] Department of Zoology, Psychology and Physiology, University of Toronto, Toronto, ON
来源：
CHRONOBIOLOGY INTERNATIONAL | 1990年 / 7卷 / 01期
基金：
英国医学研究理事会;
关键词：
Benzodiazepine; Circadian rhythm; Hamster; Key words-Activity; Triazolam;
D O I：
10.3109/07420529009056952
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In two experiments, triazolam (2.5 and 1.5 mg/animal) failed to significantly enhance the rate of re-entrainment of hamsters (Mesocricetus auratus) to an 8-hr advance of their light-dark cycle. Evidently the phase-shifting effects of triazolam are not robust. The animals did not run much in their wheels in response to the drug in these two experiments. In a third experiment, triazolam (0.5 and 2.5 mg/animal) produced phase advances of activity rhythms of hamsters in the dark. In this experiment, running in response to the drug was greater. Hamsters given triazolam but confined to their nest boxes over the next few hours did not show phase shifts. The phase-shifting effects of triazolam (when they do occur) appear to be mediated through activity increases. Triazolam-treated hamsters became ataxic in all three of these experiments. Suggestions that triazolam may be useful in ameliorating rhythm disturbances in people should be treated with a caution. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：35 / 41
页数：7
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共 12 条
  • [1] Turek F.W., Losee-Olson S., A benzodiazepine used in the treatment of insomnia phase-shifts the mammalian circadian clock, Nature, 321, pp. 167-168, (1986)
  • [2] Turek F.W., Losee-Olson S., Dose response curve for the phase-shifting effect of triazolam on the mammalian circadian clock, Life Sci, 40, pp. 1033-1038, (1987)
  • [3] Van Reeth O., Turek F.W., Adaptation of circadian rhythmicity to shift in light-dark cycle accelerated by a benzodiazepine, Am J Physiol, 253, pp. R204-R207, (1987)
  • [4] Mrosovsky N., Salmon P.A., A behavioural method for accelerating re-entrainment of rhythms to new light-dark cycles, Nature, 330, pp. 372-373, (1987)
  • [5] Mrosovsky N., Phase response curves for social entrainment, J Comp Physiol A, 162, pp. 35-46, (1988)
  • [6] Reebs S.G., Mrosovsky N., Large phase-shifts of circadian rhythms caused by induced running in a re-entrainment paradigm: the role of pulse duration and light, J Comp Physiol A, 165, pp. 819-825, (1989)
  • [7] Johnson R.F., Smale L., Moore R.Y., Morin L.P., Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine, Proc Natl Acad Sci USA, 85, pp. 5301-5304, (1988)
  • [8] Van Reeth O., Turek F.W., Stimulated activity mediates phase shifts in the hamster circadian clock induced by dark pulses or benzodiazepines, Nature, 339, pp. 49-51, (1989)
  • [9] Van Reeth O., Vanderhaeghen J.J., Turek F.W., A benzodiazepine antagonist, Ro 15–1788, can block the phase-shifting effects of triazolam on the mammalian circadian clock, Brain Res, 444, pp. 333-339, (1988)
  • [10] Ebihara S., Goto M., Oshima I., Different responses of the circadian system to GABA-active drugs in two strains of mice, J. Biol Rhythms, 3, pp. 357-364, (1988)
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