CLONING AND NUCLEOTIDE-SEQUENCE OF THE CHIMPANZEE C-MYC GENE

被引：10

作者：

ARGAUT, C ^{[1
]}

RIGOLET, M ^{[1
]}

ELADARI, ME ^{[1
]}

GALIBERT, F ^{[1
]}

机构：

[1] HOP ST LOUIS,CTR HAYEM,RECOMBINAISONS GENET LAB,CNRS,UPR 41,F-75475 PARIS 10,FRANCE

来源：

GENE | 1991年 / 97卷 / 02期

关键词：

RECOMBINANT DNA; MOLECULAR EVOLUTION; PRIMATE; COMPARATIVE STUDY; ONCOGENE; TRANSITIONS; TRANSVERSIONS;

D O I：

10.1016/0378-1119(91)90056-H

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A DNA fragment covering the chimpanzee c-myc locus was cloned from the DNA of peripheral blood lymphocytes, sequenced, and compared to its human c-myc counterpart. The two nucleotide sequences were found to be highly homologous (99%). The divergence rate between the two species was 0.4% in exons and 1.7% in introns. The different TATA-boxes described in the human myc gene were also identified in the chimpanzee sequence and an open reading frame (ORF) was observed which overlaps the chimpanzee c-myc first exon. This latter ORF contained three silent mutations with regard to the human region, whereas the chimpanzee Myc oncoprotein coded by exons 2 and 3 differed by two amino acids from the human one.

引用

页码：231 / 237

页数：7

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