Genomic Approaches to Investigate the Pathogenicity of Cryptococcus neoformans

被引：0

作者：

Mitchell, Thomas G. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Box 3803,Room 214,Jones Bldg,Res Dr, Durham, NC 27710 USA

来源：

CURRENT FUNGAL INFECTION REPORTS | 2008年 / 2卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1007/s12281-008-0025-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Cryptococcus neoformans, a model pathogenic fungus, exemplifies the application of several genome-wide approaches to investigate fungal pathogenicity. This review focuses on the application of genome-wide approaches to large populations of clinical and environmental isolates rather than to a small number of well-defined laboratory strains. Specific examples include the construction and utilization of genetic linkage maps, analyses of quantitative trait genes and loci, and the use of genome-wide genetic markers in population studies.

引用

页码：172 / 179

页数：8

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