A DETAILED REVIEW ON ORAL MUCOSAL DRUG DELIVERY SYSTEM

被引：31

作者：

Bhati, Radha ^{[1
]}

Nagrajan, Raja K. ^{[2
]}

机构：

[1] Sinhgad Coll Pharm, Pune 41, Maharashtra, India

[2] Dr MGR Med Univ, Coll Pharm, Madras, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 03期

关键词：

Oral mucosal; Buccal route; Sublingual route; Mucoadhesion;

D O I：

10.13040/IJPSR.0975-8232.3(3).659-81

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oral mucosal drug delivery system is widely applicable as novel site for administration of drug for immediate and controlled release action by preventing first pass metabolism and enzymatic degradation due to GI microbial flora. Oral mucosal drug delivery system provides local and systemic action. In this review, attention is focused to give regarding physiology of oral mucosal including tissue permeability, barriers to permeation and route of permeation, biopharmaceutics of buccal and sublingual absorption, factors affecting drug absorption, detailed information of penetration enhancers, design of oral mucosal drug delivery system and role of mucoadhesion and various theories of bioadhesion. Evaluation techniques and selection of animal model for in-vivo studies are also discussed.

引用

页码：659 / 681

页数：23

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