Failure to find a chromosome 18 pericentric linkage in families with schizophrenia

被引：14
|
作者：
DeLisi, LE
Lofthouse, R
Lehner, T
Morganti, C
Vita, A
Shields, G
Bass, N
Ott, J
Crow, TJ
机构：
[1] COLUMBIA UNIV,DEPT PSYCHIAT,NEW YORK,NY
[2] NEW YORK STATE PSYCHIAT INST & HOSP,NEW YORK,NY
[3] CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND
[4] UNIV MILAN,INST PSYCHIAT,MILAN,ITALY
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS | 1995年 / 60卷 / 06期
关键词：
chromosome; 18; schizophrenia; linkage; sibling pair analysis; affected pedigree member analysis;
D O I：
10.1002/ajmg.1320600609
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A recent report of a possible linkage of bipolar affective disorder to a pericentric region of chromosome 18 initiated the present investigation to search for a similar linkage in 32 families with schizophrenia, The results of a study using 5 markers mapped to this region show negative lod scores and only weak evidence for any Linkage by nonparametric analyses, If the previously reported finding is a true positive linkage for bipolar disorder, then either it is unlikely to be related to the genetics of schizophrenia, or the proportion of families linked to this region is small. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码：532 / 534
页数：3
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