LIPOPHILICITY OF AMINO-ACIDS

被引：35
作者：
VANDEWATERBEEMD, H
KARAJIANNIS, H
ELTAYAR, N
机构：
[1] UNIV BERN,INST PHARMAZEUT,BERN,SWITZERLAND
[2] ARES SERENO,PRECLIN PHARMACOL,GENEVA,SWITZERLAND
来源：
AMINO ACIDS | 1994年 / 7卷 / 02期
关键词：
AMINO ACIDS; LIPOPHILICITY; HYDROPHOBICITY; HYDROPATHICITY; PROTEIN AMINO ACIDS; NON-CODED AMINO ACIDS; LIPOPHILICITY PREDICTION; UNUSUAL AMINO ACIDS;
D O I：
10.1007/BF00814156
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The lipophilicity (or hydrophobicity) of amino acids is an important property relevant for protein folding and therefore of great interest in protein engineering. For peptides or peptidomimetics of potential therapeutic interest, lipophilicity is related to absorption and distribution, and thus indirectly relates to their bioactivity. A rationalization of peptide lipophilicity requires basic knowledge of the lipophilicity of the constituting amino acids. In the present contribution we will review methods to measure or calculate the lipophilicities of amino acids, including unusual amino acids, and we will make a comparison between various lipophilicity scales.
引用
收藏
页码：129 / 145
页数：17
相关论文
共 66 条
[1]   EMPIRICAL HYDROPHOBICITY SCALE FOR ALPHA-AMINO-ACIDS AND SOME OF ITS APPLICATIONS [J].
ABODERIN, AA .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1971, 2 (11) :537-&
[2]   EXTENSION OF THE FRAGMENT METHOD TO CALCULATE AMINO-ACID ZWITTERION AND SIDE-CHAIN PARTITION-COEFFICIENTS [J].
ABRAHAM, DJ ;
LEO, AJ .
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1987, 2 (02) :130-152
[3]  
Balaram P., 1992, CURR OPIN STRUC BIOL, V2, P845, DOI [10.1016/0959-440X(92)90110-S, DOI 10.1016/0959-440X(92)90110-S]
[4]   DEVELOPMENT OF HYDROPHOBICITY PARAMETERS TO ANALYZE PROTEINS WHICH BEAR POSTTRANSLATIONAL OR COTRANSLATIONAL MODIFICATIONS [J].
BLACK, SD ;
MOULD, DR .
ANALYTICAL BIOCHEMISTRY, 1991, 193 (01) :72-82
[5]   DETERMINATION OF HYDROPHOBIC PARAMETERS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY - THEORY, EXPERIMENTAL-TECHNIQUES, AND APPLICATION IN STUDIES ON QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS [J].
BRAUMANN, T .
JOURNAL OF CHROMATOGRAPHY, 1986, 373 (02) :191-225
[6]   SURFACE-TENSION OF AMINO-ACID SOLUTIONS - HYDROPHOBICITY SCALE OF AMINO-ACID RESIDUES [J].
BULL, HB ;
BREESE, K .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 161 (02) :665-670
[7]   THE STRUCTURAL DEPENDENCE OF AMINO-ACID HYDROPHOBICITY PARAMETERS [J].
CHARTON, M ;
CHARTON, BI .
JOURNAL OF THEORETICAL BIOLOGY, 1982, 99 (04) :629-644
[8]  
CHARTON M, 1990, PROG PHYS ORG CHEM, V18, P163
[9]   CHARACTERIZATION OF THE HYDROPHOBIC PROPERTIES OF AMINO-ACIDS ON THE BASIS OF THEIR PARTITION AND DISTRIBUTION COEFFICIENTS IN THE 1-OCTANOL-WATER SYSTEM [J].
CHMELIK, J ;
HUDECEK, J ;
PUTYERA, K ;
MAKOVICKA, J ;
KALOUS, V ;
CHMELIKOVA, J .
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1991, 56 (10) :2030-2041
[10]   AMINO-ACIDS CHARACTERIZATION BY GRID AND MULTIVARIATE DATA-ANALYSIS [J].
COCCHI, M ;
JOHANSSON, E .
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, 1993, 12 (01) :1-8
1234567