SUCCESSFUL TREATMENT OF POLYARTERITIS-NODOSA WITH LOW-DOSE METHOTREXATE

被引：5

作者：

BRODY, M

BOHM, I

BIWER, E

BAUER, R

机构：

来源：

HAUTARZT | 1994年 / 45卷 / 07期

关键词：

POLYARTERITIS-NODOSA; INTERLEUKIN-1; INTERLEUKIN; 8; TUMOR NECROSIS FACTOR-ALPHA; METHOTREXATE;

D O I：

10.1007/s001050050108

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report on a 45-year-old male patient who presented a classic polyarteritis nodosa (PAN). The clinical course extended over 7 years. In spite of 2 years immunosuppressive therapy with azathioprine and methylprednisolone the course was progressive. Low-dose methotrexate therapy was the only treatment that controlled the disease, leading to rapid clinical and histopathological remission. In low concentrations methotrexate acts as an IL-1 inhibitor, and it obviously suppresses the pathogenetic mechanism of PAN.

引用

页码：476 / 479

页数：4

共 11 条

[1]

BRODY M, 1993, EUR J CLIN CHEM CLIN, V31, P667

[2]

DINARELLO CA, 1987, J IMMUNOL, V139, P1902

[3]

FAUCI AS, 1991, HARRISONS PRINCIPLES, P1456

[4]

IBELGAUFTS H, 1992, LEXIKON ZYTOKINE

[5]

Kussmaul A, 1866, DEUT ARCH KLIN MED, V1, P484

[6] METHOTREXATE IN PSORIASIS - REVISED GUIDELINES [J].

ROENIGK, HH ;

AUERBACH, R ;

MAIBACH, HI ;

WEINSTEIN, GD .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1988, 19 (01) :145-156

[7]

SCHLITZ M, 1991, AKTUEL DERMATOL, V217, P162

[8]

SCHRODER JM, 1989, J IMMUNOL, V142, P244

[9] CUTANEOUS PERIARTERITIS-NODOSA - HEPATITIS-B SURFACE ANTIGEN-CONTAINING IMMUNOCOMPLEXES AND POLYMORPHONUCLEAR-LEUKOCYTE LYSOSOMAL-ENZYME RELEASE [J].

VANDEPETTE, JEW ;

JARVIS, JM ;

WILTON, JMA ;

MACDONALD, DM .

ARCHIVES OF DERMATOLOGY, 1984, 120 (01) :109-111

[10]

WAND A, 1991, AKTUEL DERMATOL, V17, P148

← 1 2 →