DEFECTIVE KILLING OF CANDIDA-ALBICANS HYPHAE BY NEUTROPHILS FROM BEIGE MICE

被引：16

作者：

JONESCARSON, J

VAZQUEZTORRES, A

BALISH, E

机构：

[1] UNIV WISCONSIN,SCH MED,DEPT SURG,MADISON,WI 53706

[2] UNIV WISCONSIN,SCH MED,DEPT MED MICROBIOL & IMMUNOL,MADISON,WI 53706

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 06期

关键词：

D O I：

10.1093/infdis/171.6.1664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The candidacidal activity of neutrophils from BALB/c, C.B-17 +/+, C,B-17 scid/scid, scid/scid-bg/bg, C57BL/6 bg/+, C57BL/6 bg/bg, NIH III bg/bg-nu/+, and bg/bg-nu/nu mice was assessed, Killing of blastoconidia was moderately deficient with neutrophils from 2 strains of homozygous beige mice; however, neutrophils from all homozygous beige strains had a significantly decreased capacity to kill Candida albicans hyphae. This is the first demonstration of a decreased capacity of beige mouse neutrophils to kill C. albicans hyphae. The latter defect could be related to the enhanced susceptibility of beige mice to candidiasis.

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页码：1664 / 1667

页数：4

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