HIPPOCAMPAL NEURONAL LOSS AND REGIONAL HYPOMETABOLISM IN TEMPORAL-LOBE EPILEPSY

被引：104
作者：
HENRY, TR
BABB, TL
ENGEL, J
MAZZIOTTA, JC
PHELPS, ME
CRANDALL, PH
机构：
[1] UNIV CALIF LOS ANGELES,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,DEPT NEUROSURG,LOS ANGELES,CA 90024
[4] UNIV CALIF LOS ANGELES,DEPT PHARMACOL,LOS ANGELES,CA 90024
[5] UNIV CALIF LOS ANGELES,DEPT RADIOL SCI,LOS ANGELES,CA 90024
来源：
ANNALS OF NEUROLOGY | 1994年 / 36卷 / 06期
关键词：
D O I：
10.1002/ana.410360620
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative [F-18]fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.
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页码：925 / 927
页数：3
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