EXPRESSION OF THE ENDOTHELIN-CONVERTING ENZYME GENE IN HUMAN TISSUES

被引：36

作者：

ROSSI, GP ^{[1
]}

ALBERTIN, G ^{[1
]}

FRANCHIN, E ^{[1
]}

SACCHETTO, A ^{[1
]}

CESARI, M ^{[1
]}

PALU, G ^{[1
]}

PESSINA, AC ^{[1
]}

机构：

[1] UNIV HOSP PADUA,SCH MED,DEPT MICROBIOL,I-35126 PADUA,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on the cDNA sequence of the human and bovine endothelin converting enzyme (ECE-1) we have developed a novel reverse transcription polymerase chain reaction to investigate the tissue expression of this gene. We were able to specifically detect the gene mRNA starting from very limited amount of tissue in all human as well as bovine tissues examined. Thus, our results confirm a widespread expression of the ECE-1 gene in human tissues, in keeping with the findings in other species, and suggest a major biological role of ECE-1. (C) 1995 Academic Press, Inc.

引用

页码：249 / 253

页数：5

共 17 条

[1] THE ENDOTHELIN-CONVERTING ENZYME FROM HUMAN UMBILICAL VEIN IS A MEMBRANE-BOUND METALLOPROTEASE SIMILAR TO THAT FROM BOVINE AORTIC ENDOTHELIAL-CELLS
AHN, K
BENINGO, K
OLDS, G
HUPE, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) : 8606 - 8610
[2] ASHIZAWA N, 1994, BIOL PHARM BULL, V17, P207
[3] ASHIZAWA N, 1994, BIOL PHARM BULL, V17, P212
[4] BATTISTINI B, 1993, LAB INVEST, V68, P600
[5] CHARACTERIZATION OF 2 ENDOTHELIN-CONVERTING ENZYMES AND THEIR PREFERENCE FOR BIG ENDOTHELIN-1 AND -2 AS SUBSTRATES
CHIOU, WJ
SHIOSAKI, K
TASKER, AS
WUWONG, JR
[J]. LIFE SCIENCES, 1994, 54 (21) : 1613 - 1619
[6] PHOSPHORAMIDON-SENSITIVE CONVERSION OF BIG ENDOTHELIN-1 AND DEGRADATION OF ENDOTHELIN-1 IN RAT-KIDNEY
FUJITA, K
MATSUMURA, Y
KITA, S
HISAKI, K
TAKAOKA, M
MORIMOTO, S
[J]. HYPERTENSION, 1994, 24 (02) : 227 - 233
[7] CDNA CLONING AND EXPRESSION OF BOVINE ENDOTHELIN-CONVERTING ENZYME
IKURA, T
SAWAMURA, T
SHIRAKI, T
HOSOKAWA, H
KIDO, T
HOSHIKAWA, H
SHIMADA, K
TANZAWA, K
KOBAYASHI, S
MIWA, S
MASAKI, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 203 (03) : 1417 - 1422
[8] ELEVATED BLOOD-PRESSURE AND CRANIOFACIAL ABNORMALITIES IN MICE DEFICIENT IN ENDOTHELIN-1
KURIHARA, Y
KURIHARA, H
SUZUKI, H
KODAMA, T
MAEMURA, K
NAGAI, R
ODA, H
KUWAKI, T
CAO, WH
KAMADA, N
JISHAGE, K
OUCHI, Y
AZUMA, S
TOYODA, Y
ISHIKAWA, T
KUMADA, M
YAZAKI, Y
[J]. NATURE, 1994, 368 (6473) : 703 - 710
[9] OHNAKA K, 1993, J BIOL CHEM, V268, P26759
[10] A MISSENSE MUTATION OF THE ENDOTHELIN-B RECEPTOR GENE IN MULTIGENIC HIRSCHSPRUNGS-DISEASE
PUFFENBERGER, EG
HOSODA, K
WASHINGTON, SS
NAKAO, K
DEWIT, D
YANAGISAWA, M
CHAKRAVARTI, A
[J]. CELL, 1994, 79 (07) : 1257 - 1266

← 1 2 →