SYNTHESIS AND BIOLOGICAL EVALUATION OF 23-OXA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3, 23-THIA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3 AND 23-OXA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3

被引：7

作者：

ALLEWAERT, K

VANBAELEN, H

BOUILLON, R

ZHAO, XY

DECLERCQ, P

VANDEWALLE, M

机构：

[1] CATHOLIC UNIV LEUVEN,ONDERWIJS NAVORSING GASTHUISBERG,EXPTL GENEESKUNDE ENDOCRINOL LAB,B-3030 HEVERLEE,BELGIUM

[2] STATE UNIV GHENT,DEPT ORGAN CHEM,ORGAN SYNTH LAB,B-9000 GHENT,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80120-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis includes the side-chain construction starting from the Inhoffen-Lythgoe diol and coupling with the A ring. Both 23-oxa- and 23-thia-analogues showed a decreased cell differentiating effect but even a more decreased calcemic effect compared with 1alpha,25-(OH)2D3.

引用

页码：1859 / 1862

页数：4

共 14 条

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