Addictive substances may induce a rapid neurological deterioration in fragile X-associated tremor ataxia syndrome: A report of two cases

被引：25
作者：
Muzar, Zukhrofi [1 ]
Adams, Patrick E. [1 ,2 ]
Schneider, Andrea [1 ,2 ]
Hagerman, Randi J. [1 ,2 ]
Lozano, Reymundo [1 ,2 ]
机构：
[1] Med Invest Neurodev Disorders MIND Inst, Sacramento, CA USA
[2] Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA
来源：
INTRACTABLE & RARE DISEASES RESEARCH | 2014年 / 3卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Substance abuse; neurological deterioration; FXTAS; premutation; opiates;
D O I：
10.5582/irdr.2014.01023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A debilitating late-onset disorder of the premutation in the FMR1 gene is the neurodegenerative disorder fragile X-associated tremor ataxia syndrome (FXTAS). We report two patients with FXTAS who have a history of substance abuse (opiates, alcohol, and cocaine) which may have exacerbated their rapid neurological deterioration with FXTAS. There has been no case report regarding the role of substance abuse in onset, progression, and severity of FXTAS symptoms. However, research has shown that substance abuse can have a negative impact on several neurodegenerative diseases, and we propose that in these cases, substance abuse contributed to a faster progression of FXTAS as well as exacerbated white matter disease.
引用
收藏
页码：162 / 165
页数：4
相关论文
共 31 条
  • [1] FXTAS New insights and the need for revised diagnostic criteria
    Apartis, Emmanuelle
    Blancher, Anne
    Meissner, Wassilios G.
    Guyant-Marechal, Lucie
    Maltete, David
    De Broucker, Thomas
    Legrand, Andre-Pierre
    Bouzenada, Hichem
    Hung Tran Thanh
    Sallansonnet-Froment, Magali
    Wang, Adrien
    Tison, Francois
    Roue-Jagot, Carole
    Sedel, Frederic
    Charles, Perrine
    Whalen, Sandra
    Heron, Delphine
    Thobois, Stephane
    Poisson, Alice
    Lesca, Gaetan
    Ouvrard-Hernandez, Anne-Marie
    Fraix, Valerie
    Palfi, Stephane
    Habert, Marie-Odile
    Gaymard, Bertrand
    Dussaule, Jean-Claude
    Pollak, Pierre
    Vidailhet, Marie
    Durr, Alexandra
    Barbot, Jean-Claude
    Gourlet, Veronique
    Brice, Alexis
    Anheim, Mathieu
    [J]. NEUROLOGY, 2012, 79 (18) : 1898 - 1907
  • [2] Corpus callosum damage in heavy marijuana use: Preliminary evidence from diffusion tensor tractography and tract-based spatial statistics
    Arnone, D.
    Barrick, T. R.
    Chengappa, S.
    Mackay, C. E.
    Clark, C. A.
    Abou-Saleh, M. T.
    [J]. NEUROIMAGE, 2008, 41 (03) : 1067 - 1074
  • [3] Prevalence and risk of migraine headaches in adult fragile X premutation carriers
    Au, J.
    Akins, R. S.
    Berkowitz-Sutherland, L.
    Tang, H-T
    Chen, Y.
    Boyd, A.
    Tassone, F.
    Nguyen, D. V.
    Hagerman, R.
    [J]. CLINICAL GENETICS, 2013, 84 (06) : 546 - 551
  • [4] Clinical features of boys with fragile X premutations and intermediate alleles
    Aziz, M
    Stathopulu, E
    Callias, M
    Taylor, C
    Turk, J
    Oostra, B
    Willemsen, R
    Patton, M
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 121B (01) : 119 - 127
  • [5] Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: Newly described fronto-subcortical dementia
    Bacalman, S
    Farzin, F
    Bourgeois, JA
    Cogswell, J
    Goodlin-Jones, BL
    Gane, LW
    Grigsby, J
    Leehey, MA
    Tassone, F
    Hagerman, RJ
    [J]. JOURNAL OF CLINICAL PSYCHIATRY, 2006, 67 (01) : 87 - 94
  • [6] Berry-Kravis E, 2010, FRAGILE X-ASSOCIATED TREMOR ATAXIA SYNDROME (FXTAS), P137, DOI 10.1007/978-1-4419-5805-1_9
  • [7] Diffusion Tensor Imaging, White Matter Lesions, the Corpus Callosum, and Gait in the Elderly
    Bhadelia, Refeeque A.
    Price, Lori Lyn
    Tedesco, Kurtis L.
    Scott, Tammy
    Qiu, Wei Qiao
    Patz, Samuel
    Folstein, Marshal
    Rosenberg, Irwin
    Caplan, Louis R.
    Bergethon, Peter
    [J]. STROKE, 2009, 40 (12) : 3816 - 3820
  • [8] White matter microstructure in opiate addiction
    Bora, Emre
    Yuecel, Murat
    Fornito, Alex
    Pantelis, Christos
    Harrison, Ben J.
    Cocchi, Luca
    Pell, Gaby
    Lubman, Dan I.
    [J]. ADDICTION BIOLOGY, 2012, 17 (01) : 141 - 148
  • [9] Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration
    Chen, Yucui
    Tassone, Flora
    Berman, Robert F.
    Hagerman, Paul J.
    Hagerman, Randi J.
    Willemsen, Rob
    Pessah, Isaac N.
    [J]. HUMAN MOLECULAR GENETICS, 2010, 19 (01) : 196 - 208
  • [10] Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder
    Chonchaiya, Weerasak
    Au, Jacky
    Schneider, Andrea
    Hessl, David
    Harris, Susan W.
    Laird, Meredith
    Mu, Yi
    Tassone, Flora
    Nguyen, Danh V.
    Hagerman, Randi J.
    [J]. HUMAN GENETICS, 2012, 131 (04) : 581 - 589
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