Antibacterial activity of 7,10-dihydroxy-8(E)-octadecenoic acid against food-borne pathogenic bacteria

A bacterial strain Pseudomonas aeruginosa (PR3) has been intensively studied to produce a novel 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) from oleic acid or natural vegetable oils containing oleic acid. However, biological properties of DOD remained unknown so far. In this study, as a trial to determine the biological properties of DOD molecule, antibacterial activities of DOD against food -borne pathogenic bacteria were determined quantitatively and qualitatively. DOD presented strong antibacterial activities against all the bacterial strains tested with an MIC value being in the range of 125-500 g/ml and there was no activity preference between gram-positive and gram-negative strains. (C) 2012 Elsevier Ltd. All rights reserved.