Short term results of topical cyclosporin A in patients with vernal keratoconjunctivitis

Objective: The aim of this study to investigate short term effects of topical cyclosporin A 0.05% in patients with vernal keratoconjunctivitis. Materials and Methods: Seventeen patients diagnosed vernal keratoconjuntivitis were classified with allergic conjunctivitis classification (absent, mild, moderate, severe) to evaluate symptoms and 5-5-5 exarhation grading scale for allergic conjuntivitis disease (mild, moderate, severe) to evaluate findings. Topical cyclosporin A (0.05%) was applied to all patients and they were evaluated in lst, 3rd and 6th months. Chi-square test was used for statistical analysis. Results: Mean age was 14 3.5 (male \ female: 12 \5). There were 11 (647%) severe hyperemia, 1 (5.9%) severe mucous discharge, 11 (647%) severe itching and 1 (5.9%) severe tearing before the treatment. Severe symptoms weren't observed in any cases after the treatment in 6th month. Hyperemia in 1 (59%) case, mucous discharge in 12 (70.5%) cases, itching in 12 (70.5%) cases, tearing in 7 (4E1%) cases were treated completely in 6th month. Alterati-ons in hyperemia (p< 0.001), mucous discharge (p< 0.001), itching (p< 0.001), tearing (p< 0.001) were significant in statistical evaluation. Mild 9 (53%) cases, moderate 7 (41.1%) cases, severe 1 (5.9%) case were classified according to 5-5-5 exarhation grading scale for allergic conjuntivitis disease before the treatment. Mild 11 (64.7%) cases, moderate 5 (29.4%) cases, severe 1 (5.9%) case were established in 6111 month. Alterations in the findings weren't established significantly in statistical evaluation. Conclusion: To apply topical cyclosporin A %CLOS in patients with vernal keratoconjuntivitis may cause to symptomatic regression significantly in short term.