C-11 LABELED POLYMER-BOUND WITTIG REAGENTS IN THE SYNTHESIS OF C-11 LABELED AROMATIC ALKENES

被引：4
|
作者：
OGREN, M
HORNFELDT, K
FASTH, KJ
LANGSTROM, B
机构：
[1] UNIV UPPSALA,INST CHEM,DEPT ORGAN CHEM,S-75121 UPPSALA,SWEDEN
[2] RES DEV CORP JAPAN,SUBFEMTOMOLE BIORECOGNIT PROJECT,S-75185 UPPSALA,SWEDEN
[3] UNIV UPPSALA,UAS,CTR PET,S-75185 UPPSALA,SWEDEN
来源：
APPLIED RADIATION AND ISOTOPES | 1995年 / 46卷 / 08期
关键词：
D O I：
10.1016/0969-8043(95)00021-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of the polymer-supported (polystyrene) C-11-labelled precursors [C-11]methyltriphenylphosphonium iodide and [C-11]cyanoalkyltriphenylphosphonium halides is presented. The polymer-supported precursors were used in Wittig reactions for the synthesis of C-11-labelled terminal and branched alkenes. C-11-labelled alkenes were formed in 2-98% decay corrected radiochemical yield, counted from [C-11]methyl iodide or hydrogen [C-11]cyanide, respectively, in 9-13 min. In the case of the branched alkenes, exclusive formation of the Z-isomer was observed.
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页码：771 / 775
页数：5
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