THE EFFECT OF N-ACETYLASPARTATE ON THE INTRACELLULAR FREE CALCIUM-CONCENTRATION IN NTERA2-NEURONS

被引：38

作者：

RUBIN, Y

LAPLACA, MC

SMITH, DH

THIBAULT, LE

LENKINSKI, RE

机构：

[1] HOSP UNIV PENN,DEPT RADIOL,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT BIOENGN,PHILADELPHIA,PA 19104

[3] UNIV PENN,DIV NEUROSURG,PHILADELPHIA,PA 19104

来源：

NEUROSCIENCE LETTERS | 1995年 / 198卷 / 03期

关键词：

N-ACETYLASPARTATE; N-METHYL-D-ASPARTATE RECEPTOR; INTRACELLULAR FREE CALCIUM; NTERA2-NEURONS;

D O I：

10.1016/0304-3940(95)12014-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca2+](i) in NTera2-neurons, While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca2+](i), high concentrations of extracellular NAA (3, 10 mM) elicited sharp and statistically significant elevations of [Ca2+](i). Different classes of antagonists of the N-methyl-D-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca2+](i), indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca2+](i).

引用

页码：209 / 212

页数：4

共 28 条

[1] MECHANISM OF ARACHIDONIC-ACID LIBERATION DURING ISCHEMIA IN GERBIL CEREBRAL-CORTEX [J].