Cell therapy in myocardial infarction

被引:35
作者
Collins, Sara D. [1 ]
Baffour, Richard [2 ]
Waksman, Ron [2 ]
机构
[1] Univ Maryland, Med Ctr, Dept Internal Med, Baltimore, MD 21201 USA
[2] Washington Hosp Ctr, Div Cardiol, 110 Irving St NW,Suite 4B-1, Washington, DC 20010 USA
关键词
Myocardial infarction; Cell therapy; Embryonic stem cells; Bone-marrow-derived cells; Myoblasts;
D O I
10.1016/j.carrev.2006.11.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heart failure is associated with a high rate of morbidity and mortality. In some patients, current treatment modalities may not be adequate to prevent myocardial remodeling, which leads to exacerbation of the disease. Cell therapy is based on the premise of replacing damaged myocardium with functional tissues. Multiple forms of stem cells, including bone marrow-derived stem cells and skeletal myoblasts, have been investigated using several delivery routes of administration. Different mechanisms have been proposed to explain the beneficial effects of cell-based therapy. These include cell transdifferentiation, cell fusion, and release of paracrine growth factors. The beneficial effects of cell therapy may involve multiple mechanisms. The encouraging results of early clinical cell therapy studies have not been sustained by subsequent robust studies. These findings suggest that many unanswered questions need to be addressed before cell therapy becomes an acceptable adjunctive treatment for heart failure. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:43 / 51
页数:9
相关论文
共 66 条
[11]   Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease [J].
Fuchs, S ;
Kornowski, R ;
Weisz, G ;
Satler, LF ;
Smits, PC ;
Okubagzi, P ;
Baffour, R ;
Aggarwal, A ;
Weissman, NJ ;
Cerqueira, M ;
Waksman, R ;
Serrruys, P ;
Battler, A ;
Moses, JW ;
Leon, MB ;
Epstein, SE .
AMERICAN JOURNAL OF CARDIOLOGY, 2006, 97 (06) :823-829
[12]   Chronic heart failure in the United States - A manifestation of coronary artery disease [J].
Gheorghiade, M ;
Bonow, RO .
CIRCULATION, 1998, 97 (03) :282-289
[13]   Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction [J].
Ghostine, S ;
Carrion, C ;
Souza, LCG ;
Richard, P ;
Bruneval, P ;
Vilquin, JT ;
Pouzet, B ;
Schwartz, K ;
Menasché, P ;
Hagège, AA .
CIRCULATION, 2002, 106 (13) :I131-I136
[14]   Transplantation of cells for cardiac repair [J].
Hassink, RJ ;
de la Rivière, AB ;
Mummery, CL ;
Doevendans, PA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (05) :711-717
[15]   Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction [J].
Herreros, J ;
Prósper, F ;
Perez, A ;
Gavira, JJ ;
Garcia-Velloso, MJ ;
Barba, J ;
Sánchez, PL ;
Cañiz, C ;
Rábago, G ;
Martí-Climent, JM ;
Hernández, M ;
López-Holgado, N ;
González-Santos, JM ;
Martín-Luengo, C ;
Alegria, E .
EUROPEAN HEART JOURNAL, 2003, 24 (22) :2012-2020
[16]   Stable benefit of embryonic stem cell therapy in myocardial infarction [J].
Hodgson, DM ;
Behfar, A ;
Zingman, LV ;
Kane, GC ;
Perez-Terzic, C ;
Alekseev, AE ;
Pucéat, M ;
Terzic, A .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (02) :H471-H479
[17]   A new method for manufacturing cardiac cell sheets using fibrin-coated dishes and its electrophysiological studies by optical mapping [J].
Itabashi, Y ;
Miyoshi, S ;
Kawaguchi, H ;
Yuasa, S ;
Tanimoto, K ;
Furuta, A ;
Shimizu, T ;
Okano, T ;
Fukuda, K ;
Ogawa, S .
ARTIFICIAL ORGANS, 2005, 29 (02) :95-103
[18]   Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells [J].
Jackson, KA ;
Majka, SM ;
Wang, HG ;
Pocius, J ;
Hartley, CJ ;
Majesky, MW ;
Entman, ML ;
Michael, LH ;
Hirschi, KK ;
Goodell, MA .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (11) :1395-1402
[19]  
Jain M, 2001, CIRCULATION, V103, P1920
[20]   Medical progress: Heart failure [J].
Jessup, M ;
Brozena, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :2007-2018