TOOLS FOR CELL SIGNALING - SYNTHESIS OF THE 3-PHOSPHATASE-RESISTANT 1,3,4,5-INSP(4) MIMIC, 1D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE 3-PHOSPHOROTHIOATE

被引：16

作者：

KOZIKOWSKI, AP ^{[1
]}

FAUQ, AH ^{[1
]}

WILCOX, RA ^{[1
]}

NAHORSKI, SR ^{[1
]}

机构：

[1] UNIV LEICESTER,DEPT CELL PHYSIOL & PHARMACOL,LEICESTER LE1 9HN,LEICS,ENGLAND

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 09期

关键词：

D O I：

10.1021/jo00088a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate, a 3-phosphatase-resistant analogue of 1,3,4,5-InsP(4) is reported, and this compound is shown to elicit Ca-45(2+) release with an EC(50) which is comparable to that of the natural metabolite, thus supporting the idea that 1,3,4,5-InsP(4) can interact with the 1,4,5-InsP(3) receptors.

引用

页码：2279 / 2281

页数：3

共 20 条

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