ENCEPHALOMYOCARDITIS (EMC) VIRUS-INDUCED MYOCARDITIS BY DIFFERENT VIRUS VARIANTS AND MOUSE STRAINS

被引：10
作者：
HIRASAWA, K
HAN, JS
TAKEDA, M
ITAGAKI, S
DOI, K
机构：
[1] Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 1992年 / 54卷 / 06期
关键词：
BALB/C MOUSE; C57BL/6; MOUSE; EMC-B; EMC-D; MYOCARDITIS;
D O I：
10.1292/jvms.54.1125
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The mode of occurrence of encephalomyocarditis (EMC) virus-induced myocarditis in mice was pathologically and virologically investigated using 2 virus variants (highly diabetogenic EMC-D and non-diabetogenic EMC-B) and 2 mouse strains (diabetes-susceptible BALB/c and diabetes-resistant C57BL/6). Mice were inoculated with 10(5) PFU/head of the virus intraperitoneally and observed up to 7 days post inoculation (7DPI). As compared with EMC-B-infected BALB/c and EMC-D-infected C57BL/6 mice, EMC-D-infected BALB/c mice developed marked myocarditis and exhibited a heart virus titer of more than 100 times above that of the others after 4DPI. Electron microscopically, small aggregations of virus-like particles, with 20-25 nm in diameter, were found in the cytoplasm of degenerated cardiomyocytes showing mitochondrial and myofibrillar degeneration in EMC-D-infected BALB/c mice.
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页码：1125 / 1129
页数：5
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