HIGH-RESOLUTION NMR-SPECTROSCOPY OF PHYSIOLOGICAL FLUIDS - FROM METABOLISM TO PHYSIOLOGY

被引：0

作者：

VIONDURY, J ^{[1
]}

NICOLI, F ^{[1
]}

TORRI, G ^{[1
]}

TORRI, J ^{[1
]}

KRIAT, M ^{[1
]}

SCIAKY, M ^{[1
]}

DAVIN, A ^{[1
]}

VIOUT, P ^{[1
]}

CONFORTGOUNY, S ^{[1
]}

COZZONE, PJ ^{[1
]}

机构：

[1] FAC MED MARSEILLE,CTR RESONANCE MAGNET BIOL & MED,CNRS,URA 1186,27 BLVD JEAN MOULIN,F-13005 MARSEILLE,FRANCE

来源：

BIOCHIMIE | 1992年 / 74卷 / 9-10期

关键词：

NMR SPECTROSCOPY; PROTON; PLASMA; CANCER; TRANSPLANTATION; METABOLIC DISEASES; CEREBROSPINAL FLUID;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High resolution NMR spectroscopy of physiological fluids provides quantitative, qualitative and dynamic information on the metabolic status of the interstitial and plasma compartments under a variety of pathophysiological conditions. The simultaneous detection and quantitation by NMR spectroscopy of numerous compounds of the intermediary metabolism offers a new insight in the understanding of the milieu interieur. NMR spectroscopy of physiological fluids offers a unique way to define and monitor the global metabolic homeostasis in humans. The development of this analytical approach is still limited by the scarcity of pluridisciplinary teams able to fully exploit the wealth of information present on the NMR spectrum of a fluid. While application in pharmacology and toxicology is already established, the main areas of current development are cancer, hereditary metabolic disorders, organ transplantation and neurological diseases.

引用

页码：801 / 807

页数：7

共 39 条

[1] [Anonymous], 1983, NEUROBIOLOGY CEREBRO
[2] BALES JR, 1985, CLIN CHEM, V31, P757
[3] BALES JR, 1984, CLIN CHEM, V30, P426
[4] HIGH-RESOLUTION PROTON NUCLEAR-MAGNETIC-RESONANCE STUDIES OF HUMAN CEREBROSPINAL-FLUID
BELL, JD
BROWN, JCC
SADLER, PJ
MACLEOD, AF
SONKSEN, PH
HUGHES, RD
WILLIAMS, R
[J]. CLINICAL SCIENCE, 1987, 72 (05) : 563 - 570
[5] ASSIGNMENT OF RESONANCES FOR ACUTE-PHASE GLYCOPROTEINS IN HIGH-RESOLUTION PROTON NMR-SPECTRA OF HUMAN-BLOOD PLASMA
BELL, JD
BROWN, JCC
NICHOLSON, JK
SADLER, PJ
[J]. FEBS LETTERS, 1987, 215 (02) : 311 - 315
[6] BELL JD, 1989, NMR BIOMED, V2, P247
[7] Chmurny G N, 1988, NMR Biomed, V1, P136, DOI 10.1002/nbm.1940010307
[8] H-1-NMR CHARACTERIZATION OF NORMAL HUMAN CEREBROSPINAL-FLUID AND THE DETECTION OF METHYLMALONIC ACID IN A VITAMIN-B12 DEFICIENT PATIENT
COMMODARI, F
ARNOLD, DL
SANCTUARY, BC
SHOUBRIDGE, EA
[J]. NMR IN BIOMEDICINE, 1991, 4 (04) : 192 - 200
[9] DETECTION OF MALIGNANT-TUMORS - WATER-SUPPRESSED PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY OF PLASMA
FOSSEL, ET
CARR, JM
MCDONAGH, J
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (22) : 1369 - 1376
[10] FREDERICO A, 1988, MAGN RES MED BIOL, V1, P305

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