ACQUIRED FACTOR-VIII INHIBITOR IN A PATIENT WITH ADENOCARCINOMA OF THE LUNG

被引：0

作者：

KONDO, H ^{[1
]}

SHIGEKIYO, T ^{[1
]}

KOJIMA, A ^{[1
]}

SAITO, S ^{[1
]}

SAIJO, N ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV PHARMACOL,1-1 TSUKIJI 5 CHOME,CHUO KU,TOKYO 104,JAPAN

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1992年 / 22卷 / 01期

关键词：

FACTOR-VIII INHIBITOR; LUNG CARCINOMA; BLEEDING TENDENCY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 58-year-old man developed an acquired factor VIII inhibitor in association with adenocarcinoma of the lung. Laboratory examinations showed a marked prolonged activated partial thromboplastin time and a low level of factor VIII activity. Further study revealed his serum to have a factor VIII inhibitor which was characterized as an IgG. Treatment with prednisolone was successful in reducing the inhibitor so that the bleeding manifested by epistaxis and subcutaneous hemorrhages in the extremities ceased. Circulating inhibitors against factor VIII associated with malignancies appear to be very rare. Fourteen patients with factor VIII inhibitors associated with malignancies were reviewed.

引用

页码：49 / 53

页数：5