HYPERHOMOCYSTEINEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS FROM A FAMILY HEALTH CARE CENTER AT HERMOSILLO, SONORA

被引：0

作者：

del Carmen Candia-Plata, Maria ^{[1
]}

Alicia Morales-Zayas, Alma ^{[1
]}

Torres-Chavez, Patricia ^{[2
]}

Bolado-Martinez, Enrique ^{[3
]}

Denisse Garcia-Villa, Miriam ^{[1
]}

Celeste Molina-Dominguez, Claudia ^{[1
]}

Alberto Rascon-Pacheco, Ramon ^{[4
]}

Alvarez-Hernandez, Gerardo ^{[1
]}

Castillon-Campana, Lucia G. ^{[3
]}

del Refugio Robles-Burgueno, Maria ^{[5
]}

机构：

[1] Univ Sonora, Dept Med & Ciencias Salud, Encinas & Rosales S-N, Hermosillo 83000, Sonora, Mexico

[2] Univ Sonora, Dept Invest & Posgrad Alimentos, Encinas & Rosales S-N, Hermosillo 83000, Sonora, Mexico

[3] Univ Sonora, Dept Ciencia Quim Biol, Encinas & Rosales S-N, Hermosillo 83000, Sonora, Mexico

[4] Inst Mexicano Seguro Social, Carretera Victoria Km 0-6, Hermosillo, Sonora 83000, Mexico

[5] Ctr Invest Alimentac & Desarrollo AC, Carretera Victoria Km 0-6, Hermosillo, Sonora 83000, Mexico

来源：

BIOTECNIA | 2011年 / 13卷 / 02期

关键词：

Type 2 diabetes mellitus; hyperhomocysteinemia; uncontrolled diabetes;

D O I：

10.18633/bt.v13i2.80

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

It has been suggested that patients with type 2 diabetes mellitus (T2DM) have higher homocysteine (Hcys) serum concentration. In this study, we demonstrated hyperhomocysteinemia in a group of 47 patients with T2DM from a first level Unit Care of Hermosillo, Sonora, and evidences of uncontrolled diabetes were found. The Hcys was measured by HPLC with fluorometric detection and markers of metabolic control were estimated by colorimetric methods (sialic acid (SA) by an enzymatic method, high sensitivity C-reactive protein (CRP) by nephelometry, and hemoglobin A1c (HbA1c) by immunoaffinity). Hcys levels in patients (15.55 mmol/L, RI=11.6-18.8) were significantly higher (p<0.05)than those from a group of 17 adults without diabetes (11.2 mu mol/L, RI=10.9-12.3), matched by sex and age. An association between Hcys and LDL-chol or plasma creatinine clearance was only found in patients with T2DM. Also, high levels of HbA1c, glucose, triglycerides, total protein, CRP, SA, and creatinine were found, which suggested a state of uncontrolled diabetes and chronic inflammation. Further studies to estimate the value of Hcys as a risk factor for vascular complications in patients with T2DM is recommended.

引用

页码：3 / 15

页数：13

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