MASSIVE CELL-DEATH OF IMMATURE HEMATOPOIETIC-CELLS AND NEURONS IN BCL-X-DEFICIENT MICE

被引：990
作者：
MOTOYAMA, N
WANG, FP
ROTH, KA
SAWA, H
NAKAYAMA, K
NAKAYAMA, K
NEGISHI, I
SENJU, S
ZHANG, Q
FUJII, S
LOH, DY
机构：
[1] WASHINGTON UNIV, SCH MED, HOWARD HUGHES MED INST, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED, DEPT MED, ST LOUIS, MO 63110 USA
[3] WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA
[4] WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA
[5] WASHINGTON UNIV, SCH MED, DEPT PATHOL, ST LOUIS, MO 63110 USA
[6] WASHINGTON UNIV, SCH MED, DEPT BIOL MOLEC, ST LOUIS, MO 63110 USA
[7] WASHINGTON UNIV, SCH MED, DEPT PHARMACOL, ST LOUIS, MO 63110 USA
[8] WASHINGTON UNIV, SCH MED, DIV CARDIOVASC MED, ST LOUIS, MO 63110 USA
来源：
SCIENCE | 1995年 / 267卷 / 5203期
关键词：
D O I：
10.1126/science.7878471
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
bcl-x is a member of the bcl-2 gene family, which may regulate programmed cell death. Mice were generated that lacked Bcl-x. The Bcl-x-deficient mice died around embryonic day 13. Extensive apoptotic cell death was evident in postmitotic immature neurons of the developing brain, spinal cord, and dorsal root ganglia. Hematopoietic cells in the liver were also apoptotic. Analyses of bcl-x double-knockout chimeric mice showed that the maturation of Bcl-x-deficient lymphocytes was diminished. The life-span of immature lymphocytes, but not mature lymphocytes, was shortened. Thus, Bcl-x functions to support the viability of immature cells during the development oi the nervous and hematopoietic systems.
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页码：1506 / 1510
页数：5
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