CEPHALOSTATIN CHEMISTRY .4. APPLICATION OF THE REICH IODOSO SYN-ELIMINATION FOR THE PREPARATION OF AN INTERMEDIATE APPROPRIATE FOR THE SYNTHESIS OF BOTH HEXACYCLIC STEROIDAL UNITS OF CEPHALOSTATIN-7

被引：23

作者：

KIM, SK ^{[1
]}

FUCHS, PL ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 39期

关键词：

D O I：

10.1016/0040-4039(94)85350-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hecogenin acetate 5 was converted to an intermediate suitable for construction of both ''North'' and ''South'' hexacyclic spiroketals present in cephalostatin 7. The key chemical transformations involved are: (I)the Reich iodoso syn-elimination of iodide 18; (2) Rhodium [II] catalyzed intermolecular oxygen alkylation of secondary neopentyl alcohol 21; and (3) Intramolecular Wadsworth-Emmons reaction to provide the ester precursor of aldehyde 4.

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页码：7163 / 7166

页数：4

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