NEUROCHEMICAL EFFECTS OF VAGUS NERVE-STIMULATION IN HUMANS

被引：74

作者：

HAMMOND, EJ

UTHMAN, BM

WILDER, BJ

BENMENACHEM, E

HAMBERGER, A

HEDNER, T

EKMAN, R

机构：

[1] GOTHENBURG UNIV, DEPT NEUROL, S-41124 GOTHENBURG, SWEDEN

[2] GOTHENBURG UNIV, DEPT HISTOL, S-41124 GOTHENBURG, SWEDEN

[3] GOTHENBURG UNIV, DEPT PHARMACOL, S-41124 GOTHENBURG, SWEDEN

来源：

BRAIN RESEARCH | 1992年 / 583卷 / 1-2期

关键词：

VAGUS NERVE; SEROTONIN; DOPAMINE; ASPARTATE; NEUROTRANSMITTER;

D O I：

10.1016/S0006-8993(10)80038-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An implanted stimulating device chronically stimulated the left cervical vagus nerve in epileptic patients. Cerebrospinal fluid concentrations of free and total gamma-aminobutyric acid, homovanillic acid, 5-hydroxyindoleacetic acid, aspartate, glutamate, aspargine, serine, glutamine, glycine, phosphoethanolamine, taurine, alanine, tyrosine, ethanolamine, valine, phenylalanine, isoleucine, vasoactive intestinal peptide, beta-endorphin, and somatostatin were measured before and after 2 months of chronic stimulation in six patients. Significant increases were seen in homovanillic acid and 5-hydroxyindoleacetic acid in three patients, and significant decreases in aspartate were seen in five patients. These changes were associated with a decrease in seizure frequency.

引用

页码：300 / 303

页数：4

共 29 条

[1] EFFECTS OF APOMORPHINE, ERGOCORNINE AND PIRIBEDIL ON AUDIOGENIC-SEIZURES IN DBA-2 MICE [J].