SUBSTANCE-P BINDING IN NORMAL NEONATAL FORESKIN

被引：9
|
作者：
ARENBERGER, P
LEDER, RO
ABRAHAM, A
CHANG, JK
FARBER, EM
机构：
[1] PSORIASIS RES INST, DEPT MOLEC & CELLULAR BIOL, PALO ALTO, CA 94301 USA
[2] PENINSULA LABS INC, BELMONT, CA USA
来源：
BRITISH JOURNAL OF DERMATOLOGY | 1995年 / 132卷 / 01期
关键词：
D O I：
10.1111/j.1365-2133.1995.tb08624.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The distribution of binding sites for NTE-biotinyl-[Arg3]-substance P (SPB) was demonstrated in neonatal. foreskin using a conjugate of streptavidin with horseradish peroxidase. The observed binding is reversible, and may be abrogated by either the non-peptide substance P receptor antagonist, CP-96,345, or by unlabelled substance P. The generalized epidermal distribution and focal dermal localization of SPB binding suggest that although NK-1 receptors are abundant in human neonatal foreskin, neuromodulatory mechanisms may play a significant role in epidermal physiology.
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页码：54 / 58
页数：5
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