GROWTH-FACTORS IN BREAST-CANCER - MITOGENESIS TO TRANSFORMATION

被引：51

作者：

DICKSON, RB

JOHNSON, MD

BANO, M

SHI, E

KUREBAYASHI, J

ZIFF, B

MARTINEZLACACI, I

AMUNDADOTTIR, LT

LIPPMAN, ME

机构：

[1] Lombardi Cancer Research Center, Georgetown University, Washington

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1992年 / 43卷 / 1-3期

关键词：

D O I：

10.1016/0960-0760(92)90189-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.

引用

页码：69 / 78

页数：10

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