MICROSOMAL CYTOCHROME P450 IN HUMAN BRAIN-REGIONS

被引：27
作者：
BHAMRE, S
ANANDATHEERTHAVARADA, HK
SHANKAR, SK
RAVINDRANATH, V
机构：
[1] NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROCHEM,BANGALORE 560029,KARNATAKA,INDIA
[2] NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROPATHOL,BANGALORE 560029,KARNATAKA,INDIA
来源：
BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 06期
关键词：
D O I：
10.1016/0006-2952(92)90390-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cytochrome P450 (P450) levels were quantitated in microsomes from human brain regions obtained at autopsy. The reduced carbon monoxide binding spectra of cortical microsomes showed two absorption maxima at 449 and 425 nm. On solubilization of the microsomes, essentially a single peak was observed at 449 nm. The P450 levels in human brain cortical microsomes varied from 0.03 to 0. 12 nmol/mg protein among the seven samples examined. The concentration of the hemeprotein present as nmol/g tissue was highest in the brain stem and cerebellum and lowest in the striatum and hippocampus.
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页码：1223 / 1225
页数：3
相关论文
共 19 条
[1]   RAT-BRAIN CYTOCHROMES P-450 - CATALYTIC, IMMUNOCHEMICAL PROPERTIES AND INDUCIBILITY OF MULTIPLE FORMS [J].
ANANDATHEERTHAVARADA, HK ;
SHANKAR, SK ;
RAVINDRANATH, V .
BRAIN RESEARCH, 1990, 536 (1-2) :339-343
[2]   ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, AND MOTONEURON DISEASE - ABIOTROPIC INTERACTION BETWEEN AGING AND ENVIRONMENT [J].
CALNE, DB ;
MCGEER, E ;
EISEN, A ;
SPENCER, P .
LANCET, 1986, 2 (8515) :1067-1070
[3]  
GUENGERICH FP, 1989, ANNU REV PHARMACOL, V29, P241
[4]  
Guengerich FP, 1982, PRINCIPLES METHODS T, P609
[5]   SKF-525-A AND CYTOCHROME-P-450 LIGANDS INHIBIT WITH HIGH-AFFINITY THE BINDING OF [H-3] DEXTROMETHORPHAN AND SIGMA LIGANDS TO GUINEA-PIG BRAIN [J].
KLEIN, M ;
CANOLL, PD ;
MUSACCHIO, JM .
LIFE SCIENCES, 1991, 48 (06) :543-550
[6]  
LU AYH, 1980, PHARMACOL REV, V31, P277
[7]  
MASTERS BSS, 1987, MAMMALIAN CYTOCHROME, V1, P107
[8]  
MASTUBARA RJ, 1976, ANAL BIOCHEM, V75, P596
[9]  
MESNIL M, 1984, ADV DRUG RES, V13, P96
[10]  
MEYERS UA, 1990, ADV DRUG RES, V19, P196
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