A MATHEMATICAL-MODEL FOR INSULIN KINETICS .3. SENSITIVITY ANALYSIS OF THE MODEL

被引：19

作者：

GEEVAN, CP

RAO, JS

RAO, GS

BAJAJ, JS

机构：

[1] ALL INDIA INST MED SCI,DEPT MED,SRB CTR CLIN PHARMACOL,NEW DELHI 110029,INDIA

[2] ALL INDIA INST MED SCI,DEPT BIOPHYS,NEW DELHI 110029,INDIA

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1990年 / 147卷 / 02期

关键词：

D O I：

10.1016/S0022-5193(05)80055-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A non-linear mathematical model involving four variables and several constants incorporating beta-cell kinetics, a glucose-insulin feedback system and a gastrointestinal absorption term had beeen applied in earlier papers to various forms of diabetes mellitus. In this paper, we examine the response of the system to variations in the parameters and to initial conditions using sensitivity analysis. It is found that such a method leads to results that are consistent with clinical findings. Further, it is suggested that such an analysis could help in making some predictions regarding future directions in the therapy of diabetes mellitus. © 1990 Academic Press Limited.

引用

页码：255 / 263

页数：9

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