PLASMA AND PLATELET FREE CATECHOLAMINE CONCENTRATIONS IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA

被引:18
作者
SMITH, CCT [1 ]
PRICHARD, BNC [1 ]
BETTERIDGE, DJ [1 ]
机构
[1] UNIV LONDON UNIV COLL,UNIV COLL & MIDDLESEX SCH MED,DEPT MED,LONDON WC1E 6JJ,ENGLAND
关键词
ADRENALINE; FAMILIAL HYPERCHOLESTEROLEMIA; NORADRENALINE; PLASMA; PLATELETS;
D O I
10.1042/cs0820113
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1. Plasma and platelet free catecholamine concentrations were measured in 22 normal subjects and in 10 treated and 11 untreated patients with heterozygous familial hypercholesterolaemia. 2. Plasma noradrenaline concentrations were significantly higher in both treated and untreated hypercholesterolaemic patients than in normal subjects. Adrenaline concentrations did not differ. 3. Platelet noradrenaline levels were higher in untreated hypercholesterolaemic patients than in normal subjects. 4. Positive correlations between the plasma noradrenaline concentration and the platelet noradrenaline concentration were observed in both normal subjects and hypercholesterolaemic patients. 5. Combining the data for normal subjects and hypercholesterolacmic patients revealed that the plasma noradrenaline concentration correlated positively with the plasma cholesterol concentration. The platelet noradrenaline concentration was also found to correlate with the plasma cholesterol concentration. 6. Our results suggest that an increased plasma cholesterol concentration may be associated with increased sympathetic nervous system activity as indicated by elevated plasma and platelet noradrenaline levels. Increases in circulating catecholamines may contribute to the platelet hyperaggregability seen in familial hypercholesterolaemia.
引用
收藏
页码:113 / 116
页数:4
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