ANTIMALARIAL ACTIVITY OF PARTHENIN AND ITS DERIVATIVES

被引：32
作者：
HOOPER, M
KIRBY, GC
KULKARNI, MM
KULKARNI, SN
NAGASAMPAGI, BA
ONEILL, MJ
PHILLIPSON, JD
ROJATKAR, SR
WARHURST, DC
机构：
[1] UNIV LONDON, SCH PHARM, LONDON WC1N 1AX, ENGLAND
[2] UNIV LONDON LONDON SCH HYG & TROP MED, LONDON WC1E 7HT, ENGLAND
[3] NATL CHEM LABS, Pune 411008, INDIA
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 09期
关键词：
PARTHENIN; PARTHENIN ADDUCTS; ANTIMALARIAL ACTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS;
D O I：
10.1016/0223-5234(90)90190-E
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Parthenin and some of its derivatives have been shown to posses significant anti-malarial activity against a multi-drug resistant strain of Plasmodium falciparum. Structure-activity relationships in this series of compounds are discussed and possible mechanisms of action considered. Molecular matching of the oxygen atoms of parthenin and the new anti-malarial drug qinghaosu shows both molecules to be amphipathic with common areas for their oxygen atoms and hydrocarbon frameworks.
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页码：717 / 723
页数：7
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