PREOPERATIVE NUTRITIONAL SUPPORT AND TUMOR-CELL KINETICS IN MALNOURISHED PATIENTS WITH GASTRIC-CANCER

被引：16

作者：

DIONIGI, P

JEMOS, V

CEBRELLI, T

FERRARI, C

FERRARI, A

BERIZZI, F

MAZZINI, G

机构：

[1] Department of Surgery, Sezione Patologia Chirurgica, University of Pavia, Pavia

[2] CNR Centro di Studio per l'Istochimica

来源：

CLINICAL NUTRITION | 1991年 / 10卷

关键词：

D O I：

10.1016/0261-5614(91)90120-2

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Stimulation of tumour growth by intensive exogenous nutrient adminstration could be a major clinical problem when nutritional support is provided in malnourished cancer patients. Nutritional repletion has been clearly shown to stimulate tumour growth in animal models but not in humans. The purpose of this prospective study was to evaluate the effect of pre-operative nutritional support on the proliferative characteristics of gastric tumour cells evaluated by H-3-thymidine (3HT) incorporation and flow cytometry (FCM). Thirty-three malnourished patients with advanced gastric cancer were allocated randomly into two groups receiving different types of nutritional support during the interval between endoscopy and operation: parenteral and/or enteral hyperalimentation (Group 1), and oral alimentation as possible or peripheral fluids (Group 2). In 16 patients with diploid tumours the percentage of 3HT labelled cells and of cells in S+G2M phase did not differ between the multiple samples taken from the mucosal surface of the neoplasia. Tumour samples showed higher mean values of cycling cells than the surrounding normal tissue. Both methods (3HT - FCM) demonstrate that tumour cell proliferation is not enhanced following a prolonged period of pre-operative artificial nutrition.

引用

页码：77 / 84

页数：8

共 31 条

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