SAFETY OF AZATHIOPRINE IN PREGNANCY IN INFLAMMATORY BOWEL-DISEASE

被引：223

作者：

ALSTEAD, EM ^{[1
]}

RITCHIE, JK ^{[1
]}

LENNARDJONES, JE ^{[1
]}

FARTHING, MJG ^{[1
]}

CLARK, ML ^{[1
]}

机构：

[1] ST MARKS HOSP,DEPT GASTROENTEROL,LONDON EC1V 2PS,ENGLAND

来源：

GASTROENTEROLOGY | 1990年 / 99卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0016-5085(90)91027-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although azathioprine has been reported to be safe during pregnancy in renal transplant recipients and patients with systemic lupus erythematosus, opinions vary whether it should be continued in pregnancy in inflammatory bowel disease. A retrospective analysis of the outcome of 16 pregnancies in 14 women receiving azathioprine for inflammatory bowel disease was performed. There was one infective complication of pregnancy (hepatitis B virus infection), but there were no congenital abnormalities or subsequent health problems in the children. This preliminary study suggests that azathioprine is safe in pregnancy in inflammatory bowel disease patients and that termination of pregnancy is not mandatory for those who conceive while taking the drug. © 1990.

引用

页码：443 / 446

页数：4

共 27 条

[1]

[Anonymous], 1980, BR J OBSTET GYNAECOL, V87, P839

[2] AN IMMUNODEFICIENCY CHARACTERIZED BY DEFECTIVE SIGNAL TRANSDUCTION IN LYMPHOCYTES-T [J].

CHATILA, T ;

WONG, R ;

YOUNG, M ;

MILLER, R ;

TERHORST, C ;

GEHA, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (11) :696-702

[3] EFFECTS ON NEONATE OF PREDNISONE AND AZATHIOPRINE ADMINISTERED TO MOTHER DURING PREGNANCY [J].

COTE, CJ ;

MEUWISSEN, HJ ;

PICKERING, RJ .

JOURNAL OF PEDIATRICS, 1974, 85 (03) :324-328

[4]

DAVIDSON AM, 1984, P EUR DIAL TRANS, V21, P54

[5] MATERNAL AZATHIOPRINE THERAPY AND DEPRESSED HEMATOPOIESIS IN THE BABIES OF RENAL-ALLOGRAFT PATIENTS [J].

DAVISON, JM ;

DELLAGRAMMATIKAS, H ;

PARKIN, JM .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1985, 92 (03) :233-239

[6] NEONATAL PANCYTOPENIA AND SEVERE COMBINED IMMUNODEFICIENCY ASSOCIATED WITH ANTENATAL ADMINISTRATION OF AZATHIOPRINE AND PREDNISONE [J].

DEWITTE, DB ;

BUICK, MK ;

CYRAN, SE ;

MAISELS, MJ .

JOURNAL OF PEDIATRICS, 1984, 105 (04) :625-628

[7]

ERKMAN J, 1972, OBSTET GYNECOL, V40, P708

[8]

FARBER M, 1976, OBSTET GYNECOL S, V48, P25

[9]

GAUDIER FL, 1988, SURG GYNECOL OBSTET, V167, P533

[10] SYSTEMIC LUPUS ERYTHEMATOSUS IN PREGNANCY TREATED WITH AZATHIOPRINE [J].

GILLIBRAND, PN .

PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1966, 59 (09) :834-+

← 1 2 3 →