AROMATASE INHIBITORS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ANDROSTENEDIONE DERIVATIVES

被引：92
作者：
MARSH, DA
BRODIE, HJ
GARRETT, W
TSAIMORRIS, CH
BRODIE, AMH
机构：
[1] WORCESTER FDN EXPTL BIOL,SHREWSBURY,MA 01545
[2] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 06期
关键词：
D O I：
10.1021/jm00383a017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：788 / 795
页数：8
相关论文
共 38 条
[21]  
COVEY DF, 1981, J BIOL CHEM, V256, P1076
[22]  
COVEY DF, 1982, MOL PHARMACOL, V21, P173
[23]   ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDROSTENE-3,6,17-TRIONE AND 1,4,6-ANDROSTATRIENE-3,17-DIONE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE-ACTIVITY [J].
COVEY, DF ;
HOOD, WF .
ENDOCRINOLOGY, 1981, 108 (04) :1597-1599
[24]   ASPECTS OF STEREOCHEMISTRY .19. DIRECTIVE EFFECTS OF REMOTE SUBSTITUENTS ON ALKALINE EPOXIDATION OF 3-OXO-DELTA4-STEROIDS [J].
HENBEST, HB ;
JACKSON, WR .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (22) :2459-+
[25]   EFFECTS OF AN INHIBITOR OF AROMATIZATION (1,4,6-ANDROSTATRIENE-3,17-DIONE) AND AN ANTI-ESTROGEN (CL-628) ON INVIVO FORMED TESTOSTERONE METABOLITES RECOVERED FROM NEONATAL RAT-BRAIN TISSUES AND PURIFIED CELL-NUCLEI - IMPLICATIONS FOR SEXUAL DIFFERENTIATION OF RAT-BRAIN [J].
LIEBERBURG, I ;
WALLACH, G ;
MCEWEN, BS .
BRAIN RESEARCH, 1977, 128 (01) :176-181
[26]   SYNTHESIS AND EVALUATION OF 10-BETA-SUBSTITUTED 4-ESTRENE-3,17-DIONES AS INHIBITORS OF HUMAN PLACENTAL MICROSOMAL AROMATASE [J].
MARCOTTE, PA ;
ROBINSON, CH .
STEROIDS, 1982, 39 (03) :325-344
[27]   SUBSTRATE-INDUCED INACTIVATION OF AROMATASE BY ALLENIC AND ACETYLENIC STEROIDS [J].
METCALF, BW ;
WRIGHT, CL ;
BURKHART, JP ;
JOHNSTON, JO .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (11) :3221-3222
[28]   GEWINNUNG VON 1-4-BISDEHYDRO-3-OXO-STEROIDEN [J].
MEYSTRE, C ;
FREY, H ;
VOSER, W ;
WETTSTEIN, A .
HELVETICA CHIMICA ACTA, 1956, 39 (03) :734-742
[29]   NORETHISTERONE, A MAJOR INGREDIENT OF CONTRACEPTIVE PILLS, IS A SUICIDE INHIBITOR OF ESTROGEN BIOSYNTHESIS [J].
OSAWA, Y ;
YARBOROUGH, C ;
OSAWA, Y .
SCIENCE, 1982, 215 (4537) :1249-1251
[30]   EFFECTS OF 4-HYDROXY-4-ANDROSTENE-3, 17-DIONE AND 10-PROPARGYLESTR-4-ENE-3, 17-DIONE ON THE METABOLISM OF ANDROSTENEDIONE IN HUMAN-BREAST CARCINOMA AND BREAST ADIPOSE TISSUES [J].
PEREL, E ;
DAVIS, SP ;
COVEY, DF ;
KILLINGER, DW .
STEROIDS, 1981, 38 (04) :397-405
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