CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF FLUOXETINE

被引：31

作者：

CHENEVERT, R

FORTIER, G

机构：

来源：

CHEMISTRY LETTERS | 1991年 / 09期

关键词：

D O I：

10.1246/cl.1991.1603

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Both enantiomers of fluoxetine have been synthesized from ethyl benzoylacetate. The key step is the enantioselective reduction of the starting material by baker's yeast.

引用

页码：1603 / 1606

页数：4

共 17 条

[1] BROWN HC, 1986, MODERN SYNTHETIC MET, V4, P307
[2] ENANTIOSELECTIVE AND PRACTICAL SYNTHESES OF R-FLUOXETINE AND S-FLUOXETINE
COREY, EJ
REICHARD, GA
[J]. TETRAHEDRON LETTERS, 1989, 30 (39) : 5207 - 5210
[3] BAKERS-YEAST MEDIATED TRANSFORMATIONS IN ORGANIC-CHEMISTRY
CSUK, R
GLANZER, BI
[J]. CHEMICAL REVIEWS, 1991, 91 (01) : 49 - 97
[4] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS
DALE, JA
MOSHER, HS
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (02) : 512 - 519
[5] DAVIES HG, 1989, BIOTRANSFORMATIONS
[6] ASYMMETRIC REDUCTION OF CARBONYL-COMPOUNDS BY YEAST .2. PREPARATION OF OPTICALLY-ACTIVE ALPHA-HYDROXY AND BETA-HYDROXY CARBOXYLIC-ACID DERIVATIVES
DEOL, BS
RIDLEY, DD
SIMPSON, GW
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1976, 29 (11) : 2459 - 2467
[7] ASYMMETRIC-SYNTHESIS OF BOTH ENANTIOMERS OF TOMOXETINE AND FLUOXETINE - SELECTIVE REDUCTION OF 2,3-EPOXYCINNAMYL ALCOHOL WITH RED-AL
GAO, Y
SHARPLESS, KB
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (17) : 4081 - 4084
[8] IVES JL, 1989, ANNU REP MED CHEM, V24, P21
[9] A NEW CHEMOENZYMATIC ENANTIOSELECTIVE SYNTHESIS OF R-(-)-TOMOXETINE, (R)-FLUOXETINE AND (S)-FLUOXETINE
KUMAR, A
NER, DH
DIKE, SY
[J]. TETRAHEDRON LETTERS, 1991, 32 (16) : 1901 - 1904
[10] MANZOCCHI A, 1987, J CHEM SOC P, V1, P2753

← 1 2 →