SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL PYRIMIDOBENZIMIDAZOLE DERIVATIVES

Pyrimidobenzimidazole derivatives were synthesized, by reaction of 2'-amino-5'-cyano-4'hydroxy pyrimido[1,2-a] benzimidazole 1(a-b) with paraformaldehyde in formic acid to give 2(a-b) which upon further reaction with methyl chloroacetate in presence of anhydrous potassium carbonate in acetone gave 3(a-b) which on condensation with hydrazine hydrazide gave compounds 4(a-b) which on further treatment with carbon disulfide in absolute ethanol in presence of potassium hydroxide formed potassium dithiocarbazate salt which when refluxed with hydrazine hydrate gave 5(a-b). These compounds were evaluated for their antimicrobial and antifungal activities which showed promising results. The structure of all synthesized compounds was confirmed by IR, (HNMR)-H-1, mass spectral data and elemental analysis.