Regulative Roles of Ghrelin in Ingestive Behavior, Upper Gastrointestinal Motility, and Secretion

被引：0

作者：

Ueda, Hirotaka ^{[1
]}

Yagi, Takakazu ^{[1
]}

Amitani, Haruka ^{[2
]}

Asakawa, Akihiro ^{[2
]}

Miyawaki, Shouichi ^{[1
]}

Inui, Akio ^{[2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Orthodont & Dentofacial Orthoped, Kagoshima 8908520, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan

来源：

CURRENT NUTRITION & FOOD SCIENCE | 2012年 / 8卷 / 03期

关键词：

Acyl ghrelin; des-acyl ghrelin; food intake; ingestive behavior; gastric acid secretion; gastrointestinal motility; oral functions;

D O I：

10.2174/157340112802651112

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Ghrelin was recently identified as the first endogenous ligand for growth hormone secretagogue receptors (previously known as orphan receptors). Two major molecular forms of ghrelin are found in the stomach and plasma: acyl ghrelin with O-n-octanoylated serine at position 3 and des-acyl ghrelin. Interestingly, these distinct molecular forms play contrasting roles in ingestive behavior, upper gastrointestinal motility, and gastric acid secretion. Acyl ghrelin stimulates food intake both in fed and fasted rodents and induces adiposity, alleviates ingestive behavior, stimulates gastrointestinal motor activity and gastric acid secretion, and accelerates gastric emptying in several species. In contrast, des-acyl ghrelin has been demonstrated to disrupt gastric motility in rats and delay gastric emptying in mice and rats. Thus, acyl ghrelin is a potent stimulator of ingestive behavior, gastrointestinal motility, and gastric acid secretion, whereas des-acyl ghrelin exerts opposing effects on ingestive behavior and gastrointestinal motility but does not affect gastric acid secretion. Ghrelin is expected to be used in various applications such as therapeutic strategies for obesity, anorexia, cachexia, and cardiovascular disease in the clinical setting. In this article, we review the evidence on the roles of acyl ghrelin and des-acyl ghrelin in the regulation of ingestive behavior, upper gastrointestinal motility, and gastric acid secretion in mammals; moreover, we mention the effects of ghrelin on oral functions.

引用

页码：188 / 195

页数：8