High-Grade Prostatic Intraepithelial Neoplasia

被引：7
作者：
Klink, Joseph C. [1 ]
Miocinovic, Ranko [1 ]
Galluzzi, Cristina Magi [1 ]
Klein, Eric A. [1 ]
机构：
[1] Glickman Urol & Kidney Inst, 9500 Euclid Ave Q10-1, Cleveland, OH 44125 USA
来源：
KOREAN JOURNAL OF UROLOGY | 2012年 / 53卷 / 05期
关键词：
HGPIN; High grade prostatic intraepithelial neoplasia; Prostate biopsy; Prostate cancer;
D O I：
10.4111/kju.2012.53.5.297
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. Nevertheless, a literature review supports that large-volume HGPIN and multiple cores of involvement at the initial biopsy should prompt a repeat biopsy of the prostate within 1 year. No treatment is recommended for HGPIN to slow its progression to cancer.
引用
收藏
页码：297 / 303
页数：7
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