Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature

被引：13

作者：

Lopes, Henrique ^{[1
]}

Pereira, Caio A. D. ^{[1
]}

Zucca, Luis E. R. ^{[1
]}

Serrano, Sergio V. ^{[1
]}

Silva, Sandra R. M. ^{[2
]}

Camparoto, Marjori L. ^{[3
]}

Carcano, Flavio M. ^{[1
]}

机构：

[1] Barretos Canc Hosp, Dept Med Oncol, Barretos, SP, Brazil

[2] Barretos Canc Hosp, Dept Pathol, Barretos, SP, Brazil

[3] Barretos Canc Hosp, Ctr Res Mol Oncol, Dept Cytogenet, Barretos, SP, Brazil

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2013年 / 7卷

关键词：

synovial sarcoma; kidney neoplasms; SYT-SSX fusion protein; chemotherapy;

D O I：

10.4137/CMO.S12243

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary synovial sarcoma (SS) of the kidney is a rare neoplasm and its presenting features are similar to other common renal tumors, making early diagnosis difficult. To date, few cases have been reported in the literature. Primary renal SSs can exist in either a monophasic or a biphasic pattern, the former being more common and tending to have a better prognosis than the biphasic variant. Herein we describe a case of primary renal SS that was diagnosed based on histopathology and immunohistochemistry after radical nephrectomy. Fusion gene product analysis was also done by FISH and RT-PCR. Patient follow-up and literature review are presented, focused on systemic therapy. We highlight that these tumors should be correctly diagnosed as clinical results and specific treatment are distinct from primary epithelial renal cell carcinoma. Adjuvant chemotherapy should be tailored for each patient in the management of disease, although its role still remains unclear.

引用

页码：257 / 262

页数：6

共 28 条

[11] Kawai A., Woodruff J., Healey J., Brennan M., Antonescu C., Ladanyi M., SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma, N Engl J Med., 338, 3, pp. 153-160, (1998)
[12] Surace C., Panagopoulos L., Palsson E., Rocchi M., Mandahl N., Mertens F., A novel FISH assay for SS18-SSX fusion type in synovial sarcoma, Lab lnvest., 84, 9, pp. 1185-1192, (2004)
[13] Amary M., Berisha F., Bernardi F.C., Et al., Detection of SS18-SSX fusion transcripts in formalin-Bxed parafin-embedded neoplasms: Analysis of conventional RT-PCR, qRT-PCR and dual color FlSH as diagnostic tools for synovial sarcoma, Mod Pathol., 20, 4, pp. 482-496, (2007)
[14] Karavasilis V., Seddon B.M., Ashley S., Al-Muderis O., Fisher C., Judson I., Significant clinical benefit of first-line palliative chemotherapy in advanced soft-tissue sarcoma: Retrospective analysis and identification of prognostic factors in 488 patients, Cancer., 112, 7, pp. 1585-1591, (2008)
[15] Coindre J., Terrier P., Bui N., Et al., Prognostic factors in adult patients with locally controlled soft tissue sarcoma: A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group, J Clin Oncol., 14, 3, pp. 869-877, (1996)
[16] Pisters P., Leung D., Woodruff J., Shi W., Brennan M.F., Analysis of prognostic factors in 1041 patients with localized soft tissue sarcomas of the extremities, J Clin Oncol., 14, 5, pp. 1679-1689, (1996)
[17] Ladanyi M., Antonescu C.R., Leung D.H., Et al., Impact of SYT-SSX fusion type on clinical behavior of synovial sarcoma: A multi-institutional retrospective study of 243 patients, Cancer Res., 62, 1, pp. 135-140, (2002)
[18] Przybyl J., Sciot R., Rutkowski P., Et al., Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: Description of three new cases, Tumor Biol., 33, 6, pp. 2245-2253, (2012)
[19] Amary M.F.C., Diss T.C., Flanagan A.M., Molecular characterization of a novel variant of a SYT-SSX1 fusion transcript in synovial sarcoma, Histopathology., 51, 4, pp. 559-561, (2007)
[20] Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: Meta-analysis of individual data, Lancet., 350, 9092, pp. 1647-1654, (1997)

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