Interleukin-17 and type 17 helper T cells in cancer management and research

被引：20

作者：

Llosa, Nicolas J. ^{[1
]}

Geis, Abby L. ^{[2
]}

Orberg, Erik Thiele ^{[2
]}

Housseau, Franck ^{[2
]}

机构：

[1] Johns Hopkins Univ, Dept Pediat Oncol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21205 USA

来源：

IMMUNOTARGETS AND THERAPY | 2014年 / 3卷

关键词：

biomarkers; inflammation; tumor microenvironment;

D O I：

10.2147/ITT.S56529

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since their recent discovery, T helper 17 (Th17) cells have been frequently detected in the tumor microenvironment of many malignancies, but their clinical implications remain largely unknown. Interleukin-17 (IL-17) detection is commonly related with poor outcomes in colorectal cancers, yet its presence is associated with antitumor responses in ovarian carcinomas. Numerous experimental models illustrate the divergent roles of Th17 cells in tumor immunity, which appears to be mainly dependent on the tumor context (type, location, and stage of cancer). It is recognized that IL-17 is produced by a variety of cell types and that Th17 cells are endowed with a unique functional plasticity. Therefore, when trying to elucidate potential immune biomarkers and immunotargets, it is extremely important to make a clear dissociation between strategies targeting Th17 versus its hallmark cytokine, IL-17. In this review, we will summarize the data regarding the detection of IL-17 and Th17 in human cancers, consider the experimental evidence on their respective roles in antitumor activity, and discuss the potential of IL-17 as an immune target for therapeutic interventions.

引用

页码：39 / 53

页数：15

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