Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes

被引：30

作者：

Taneja, Pankaj ^{[1
,2
]}

Zhu, Sinan ^{[1
,3
]}

Maglic, Dejan ^{[1
,2
,3
]}

Fry, Elizabeth A. ^{[1
,2
]}

Kendig, Robert D. ^{[1
,2
]}

Inoue, Kazushi ^{[1
,2
,3
]}

机构：

[1] Wake Forest Univ Hlth Sci, Dept Pathol, Winston Salem, NC 27157 USA

[2] Wake Forest Univ Hlth Sci, Dept Canc Biol, Winston Salem, NC 27157 USA

[3] Wake Forest Univ Hlth Sci, Grad Program Mol Med, Med Ctr, Winston Salem, NC 27157 USA

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2011年 / 5卷

关键词：

p53; Rb; Ink4a/Arf; BRCA; tumor suppressor genes; transgenic mice; knockout mice; mouse models; ageing;

D O I：

10.4137/CMO.S7516

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is caused by multiple genetic alterations leading to uncontrolled cell proliferation through multiple pathways. - Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in - regulating the cell cycle, apoptosis, or cell differentiation, or maintenance of genomic integrity. Tumor suppressor mouse models are the most frequently used animal models in cancer research. The anti-tumorigenic functions of TSGs, and their role in development and differentiation, and inhibition of oncogenes are discussed. In this review, we summarize some of the important transgenic and knockout mouse models for TSGs, including Rb, p53, Ink4a/Arf, Brca1/2, and their related genes.

引用

页码：235 / 257

页数：23

共 186 条

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