OXYGEN BUBBLING CAN IMPROVE THE LABELING OF PENTAVALENT TC-99M DIMERCAPTOSUCCINIC ACID

被引：9

作者：

KOBAYASHI, H ^{[1
]}

SUZUKI, KH ^{[1
]}

SAKAHARA, H ^{[1
]}

YAO, ZS ^{[1
]}

YOKOYAMA, A ^{[1
]}

KONISHI, J ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT RADIOPHARMACEUT CHEM,SAKYO KU,KYOTO,JAPAN

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1995年 / 22卷 / 06期

关键词：

PENTAVALENT TC-99M DIMERCAPTOSUCCINIC ACID; OXYGEN; KIDNEY; RENAL SCINTIGRAPHY;

D O I：

10.1007/BF00817283

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

It has previously been reported that almost all of the trivalent technetium-99m dimercaptosuccinic acid (Tc-99m (III) DMSA) present in the labelling product of pentavalent technetium-99m DMSA (Tc-99m (V) DMSA) can be changed into Tc-99m (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of Tc-99m. The method of labelling of Tc-99m (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated Tc-99m (III) DMSA into Tc-99m (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.

引用

页码：559 / 562

页数：4

共 10 条

[1] CLARKE SEM, 1988, J NUCL MED, V29, P33
[2] HIRANO T, 1994, EUR J NUCL MED, V21, P82
[3] CHEMICAL AND BIOLOGICAL STUDIES ON TC-99M-DMS .2. EFFECT OF SN(II) ON FORMATION OF VARIOUS TC-DMS COMPLEXES
IKEDA, I
INOUE, O
KURATA, K
[J]. INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1976, 27 (12): : 681 - 688
[4] SOFT-TISSUE TUMORS - DIAGNOSIS WITH TC-99M (V) DIMERCAPTOSUCCINIC ACID SCINTIGRAPHY
KOBAYASHI, H
SAKAHARA, H
HOSONO, M
SHIRATO, M
ENDO, K
KOTOURA, Y
YAMAMURO, T
KONISHI, J
[J]. RADIOLOGY, 1994, 190 (01) : 277 - 280
[5] A COMPARISON OF THE TUMOR-SEEKING AGENT TC-99M(V) DIMERCAPTOSUCCINIC ACID AND THE RENAL IMAGING AGENT TC-99M DIMERCAPTOSUCCINIC ACID IN HUMANS
OHTA, H
ISHII, M
YOSHIZUMI, M
ENDO, K
SAKAHARA, H
NAKAJIMA, T
YOMODA, I
MASUDA, H
HORIUCHI, K
HATA, N
YOKOYAMA, A
TORIZUKA, K
[J]. CLINICAL NUCLEAR MEDICINE, 1985, 10 (03) : 167 - 170
[6] OHTA H, 1984, J NUCL MED, V25, P323
[7] WASHBURN LC, 1994, J NUCL MED, V35
[8] A convenient method for the preparation of 99mTc(V)dimercaptosuccinic acid (99mTc(V)-DMSA)
Westera, G.
Gadze, A.
Horst, W.
[J]. International Journal of Applied Radiation and Isotopes, 1985, 36 (04): : 311 - 312
[9] THE DESIGN OF A PENTAVALENT TC-99M-DIMERCAPTOSUCCINATE COMPLEX AS A TUMOR IMAGING AGENT
YOKOYAMA, A
HATA, N
HORIUCHI, K
MASUDA, H
SAJI, H
OHTA, H
YAMAMOTO, K
ENDO, K
TORIZUKA, K
[J]. INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE & BIOLOGY, 1985, 12 (04): : 273 - &
[10] YOMODA I, 1987, JPN J NUCL MED, V24, P77

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