HYPOXIA-ISCHEMIA IN THE NEONATAL RAT-BRAIN - HISTOPATHOLOGY AFTER POSTTREATMENT WITH NMDA AND NON-NMDA RECEPTOR ANTAGONISTS

被引：0

作者：

HAGBERG, H

GILLAND, E

DIEMER, NH

ANDINE, P

机构：

[1] GOTHENBURG UNIV,DEPT OBSTET & GYNECOL,GOTHENBURG,SWEDEN

[2] UNIV COPENHAGEN,INST NEUROBIOL,DEPT ANAT & CELL BIOL,COPENHAGEN,DENMARK

[3] UNIV COPENHAGEN,INST NEUROPATHOL,COPENHAGEN,DENMARK

来源：

BIOLOGY OF THE NEONATE | 1994年 / 66卷 / 04期

关键词：

NEONATE; BRAIN DAMAGE; ISCHEMIA; HYPOXIA; EXCITATORY AMINO ACIDS; NMDA RECEPTORS; AMPA RECEPTORS; HISTOPATHOLOGY;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In a model of perinatal hypoxic-ischemic brain damage, we examined the neuroprotective efficacy of posttreatment with the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist NBQX. Unilateral brain damage developed in 95% of rat pups subjected to hypoxia-ischemia with a 27.8 +/- 1.2% weight deficit of the damaged hemisphere. MK-801 in doses of 0.3 and 0.5 mg/kg i.p. reduced the brain damage by 61% (p < 0.001) and 43% (p < 0.001), respectively. A higher dose of MK-801 (0.75 mg/kg) did not offer neuroprotection. Treatment with NBQX (40 mg/kg) reduced the hemispheric lesion by 28% (p < 0.05). In conclusion, posttreatment with both NBQX and low doses of MK-801 reduced perinatal brain damage. The NMDA receptor antagonist offered stronger neuroprotection which is in agreement with a proposed NMDA receptor hyperactivity around postnatal day 7 in rats.

引用

页码：205 / 213

页数：9

共 55 条

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