HYPOXIA-ISCHEMIA IN THE NEONATAL RAT-BRAIN - HISTOPATHOLOGY AFTER POSTTREATMENT WITH NMDA AND NON-NMDA RECEPTOR ANTAGONISTS

被引:0
作者
HAGBERG, H
GILLAND, E
DIEMER, NH
ANDINE, P
机构
[1] GOTHENBURG UNIV,DEPT OBSTET & GYNECOL,GOTHENBURG,SWEDEN
[2] UNIV COPENHAGEN,INST NEUROBIOL,DEPT ANAT & CELL BIOL,COPENHAGEN,DENMARK
[3] UNIV COPENHAGEN,INST NEUROPATHOL,COPENHAGEN,DENMARK
来源
BIOLOGY OF THE NEONATE | 1994年 / 66卷 / 04期
关键词
NEONATE; BRAIN DAMAGE; ISCHEMIA; HYPOXIA; EXCITATORY AMINO ACIDS; NMDA RECEPTORS; AMPA RECEPTORS; HISTOPATHOLOGY;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In a model of perinatal hypoxic-ischemic brain damage, we examined the neuroprotective efficacy of posttreatment with the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist NBQX. Unilateral brain damage developed in 95% of rat pups subjected to hypoxia-ischemia with a 27.8 +/- 1.2% weight deficit of the damaged hemisphere. MK-801 in doses of 0.3 and 0.5 mg/kg i.p. reduced the brain damage by 61% (p < 0.001) and 43% (p < 0.001), respectively. A higher dose of MK-801 (0.75 mg/kg) did not offer neuroprotection. Treatment with NBQX (40 mg/kg) reduced the hemispheric lesion by 28% (p < 0.05). In conclusion, posttreatment with both NBQX and low doses of MK-801 reduced perinatal brain damage. The NMDA receptor antagonist offered stronger neuroprotection which is in agreement with a proposed NMDA receptor hyperactivity around postnatal day 7 in rats.
引用
收藏
页码:205 / 213
页数:9
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