STRIATAL EXTRACTS FROM PATIENTS WITH PARKINSONS-DISEASE PROMOTE DOPAMINE NEURON GROWTH IN MESENCEPHALIC CULTURES

被引：52

作者：

CARVEY, PM

PTAK, LR

NATH, ST

SIERENS, DK

MUFSON, EJ

GOETZ, CG

KLAWANS, HL

机构：

[1] Department of Neurological Sciences, Rush Presbyterian St. Luke’s Medical Center, Chicago

来源：

EXPERIMENTAL NEUROLOGY | 1993年 / 120卷 / 01期

关键词：

D O I：

10.1006/exnr.1993.1049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The caudate, putamen, and cerebellum from five patients with Parkinson's disease (PD) and five normal, aged controls were studied to determine if cell-free extracts from these tissues influenced dopamine neuron growth in culture. Cultures incubated with extracts of the caudate and putamen, but not the cerebellum, from PD patients contained more tyrosine hydroxylase immunoreactive neurons than aged controls. These data suggest that the parkinsonian striatum compensates for dopamine loss by increasing neurotrophic factor production. © 1993 Academic Press, Inc.

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页码：149 / 152

页数：4

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