CHARACTERIZATION OF AN INVITRO BLOOD-BRAIN-BARRIER MODEL SYSTEM FOR STUDYING DRUG TRANSPORT AND METABOLISM

被引：247
作者：
AUDUS, KL [1 ]
BORCHARDT, RT [1 ]
机构：
[1] UNIV KANSAS, SCH PHARM, DEPT PHARMACEUT CHEM, LAWRENCE, KS 66045 USA
来源：
PHARMACEUTICAL RESEARCH | 1986年 / 3卷 / 02期
关键词：
D O I：
10.1023/A:1016337202335
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：81 / 87
页数：7
相关论文
共 28 条
[1]  
[Anonymous], 1979, CONCEPT BLOOD BRAIN
[2]  
AUDUS KL, J NEUROCHEM
[3]  
BARANCZYKKUZMA A, J NEUROCHEM
[4]   POLARITY OF BLOOD-BRAIN-BARRIER - NEUTRAL AMINO-ACID TRANSPORT INTO ISOLATED BRAIN CAPILLARIES [J].
BETZ, AL ;
GOLDSTEIN, GW .
SCIENCE, 1978, 202 (4364) :225-227
[5]   BRAIN MICROVESSEL ENDOTHELIAL-CELLS IN TISSUE-CULTURE - A MODEL FOR STUDY OF BLOOD-BRAIN-BARRIER PERMEABILITY [J].
BOWMAN, PD ;
ENNIS, SR ;
RAREY, KE ;
BETZ, AL ;
GOLDSTEIN, GW .
ANNALS OF NEUROLOGY, 1983, 14 (04) :396-402
[6]  
BOWMAN PD, 1981, IN VITRO CELL DEV B, V17, P353
[7]   JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN VERTEBRATE BRAIN [J].
BRIGHTMA.MW ;
REESE, TS .
JOURNAL OF CELL BIOLOGY, 1969, 40 (03) :648-+
[8]   NEUTRAL AMINO-ACID-TRANSPORT PROPERTIES OF CEREBRAL ENDOTHELIAL-CELLS INVITRO [J].
CANCILLA, PA ;
DEBAULT, LE .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1983, 42 (02) :191-199
[9]   EXPRESSION OF GAMMA-GLUTAMYL-TRANSPEPTIDASE IN A TRANSFORMED RAT CEREBRAL ENDOTHELIAL CELL-LINE [J].
CASPERS, ML ;
DIGLIO, CA .
BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 803 (1-2) :1-6
[10]  
DEBAULT LE, 1979, IN VITRO CELL DEV B, V15, P473
123