THE GENETICS OF MENTAL-RETARDATION

被引：14
作者：
THAPAR, A
GOTTESMAN, II
OWEN, MJ
ODONOVAN, MC
MCGUFFIN, P
机构：
[1] UNIV VIRGINIA, DEPT PSYCHOL, CHARLOTTESVILLE, VA 22903 USA
[2] UNIV WALES COLL MED, INST MED GENET, CARDIFF CF4 4XN, S GLAM, WALES
[3] MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA
来源：
BRITISH JOURNAL OF PSYCHIATRY | 1994年 / 164卷
关键词：
D O I：
10.1192/bjp.164.6.747
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Individuals affected by mental retardation are a clinically and aetiologically heterogeneous group. This heterogeneity is particularly highlighted when we consider the genetics of mental retardation. Recent advances in molecular genetic techniques have enabled us to understand more about the molecular basis of several genetic syndromes associated with mental retardation. In contrast, where there is no discrete cause, the interplay of genetic and environmental influences remains poorly understood.
引用
收藏
页码：747 / 758
页数：12
相关论文
共 90 条
[1]   THE BIOLOGICAL ORIGIN OF MILD MENTAL-RETARDATION - A CRITICAL-REVIEW [J].
AKESSON, HO .
ACTA PSYCHIATRICA SCANDINAVICA, 1986, 74 (01) :3-7
[2]  
ANGELMAN H, 1965, DEV MED CHILD NEUROL, V7, P681
[3]   FAMILIAL STUDIES OF INTELLIGENCE - A REVIEW [J].
BOUCHARD, TJ ;
MCGUE, M .
SCIENCE, 1981, 212 (4498) :1055-1059
[4]   4TH INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION [J].
BROWN, WT ;
JENKINS, E ;
NERI, G ;
LUBS, H ;
SHAPIRO, LR ;
DAVIES, KE ;
SHERMAN, S ;
HAGERMAN, R ;
LAIRD, C .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1991, 38 (2-3) :158-172
[5]   THE RECURRENCE RISKS FOR MILD IDIOPATHIC MENTAL-RETARDATION [J].
BUNDEY, S ;
THAKE, A ;
TODD, J .
JOURNAL OF MEDICAL GENETICS, 1989, 26 (04) :260-266
[6]   PRADER-WILLI SYNDROME - CURRENT UNDERSTANDING OF CAUSE AND DIAGNOSIS [J].
BUTLER, MG .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1990, 35 (03) :319-332
[7]   ASSESSMENT OF EFFECTS OF SOCIO-ECONOMIC STATUS ON IQ IN A FULL CROSS-FOSTERING STUDY [J].
CAPRON, C ;
DUYME, M .
NATURE, 1989, 340 (6234) :552-554
[8]   KLINEFELTER SYNDROME IN SARDINIA AND SCOTLAND - COMPARATIVE STUDIES OF PARENTAL AGE AND OTHER ETIOLOGICAL FACTORS IN 47,XXY [J].
CAROTHERS, AD ;
FILIPPI, G .
HUMAN GENETICS, 1988, 81 (01) :71-75
[9]   RECURRENCE RISK IN PRADER-WILLI SYNDROME [J].
CASSIDY, SB .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 28 (01) :59-60
[10]   FRAGILE (X) X-LINKED MENTAL-RETARDATION .1. RELATIONSHIP BETWEEN AGE AND INTELLIGENCE AND THE FREQUENCY OF EXPRESSION OF FRAGILE (X)(Q28) [J].
CHUDLEY, AE ;
KNOLL, J ;
GERRARD, JW ;
SHEPEL, L ;
MCGAHEY, E ;
ANDERSON, J .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1983, 14 (04) :699-712
123456789